Chromosomal banding patterns in patients with acute nonlymphocytic leukemia

Journal Article · Tue Jan 01 04:00:00 EST 1980 · Cancer Genet. Cytogenet.; (United States)

DOI:https://doi.org/10.1016/0165-4608(80)90020-5· OSTI ID:6600627

Testa, J R; Rowley, J D

Approximately 50% of acute nonlymphocytic leukemia (ANLL) patients studied with banding techniques have detectable clonal karyotypic abnormalities. Although there is considerable variability, certain nonrandom abnormalities are observed, including trisomy 8, monosomy 7, and the 8;21 translocation (frequently accompanied by loss of an X or Y). The 15;17 translocation is highly specific for acute promyelocytic leukemia. Clonal evolution of the karyotype can be observed in a significant number of ANLL patients for whom serial cytogenetic analyses are obtained. Gain of a No. 8 is the most frequently observed evolutionary change. Bone marrow cells from paients who develop ANLL following treatment of a previous malignancy often have hypodiploid modal numbers and frequently show loss of all or part of a chromosome No. 5 or No. 7.

• Research Organization: Univ. of Chicago, IL
• OSTI ID: 6600627
• Journal Information: Cancer Genet. Cytogenet.; (United States), Journal Name: Cancer Genet. Cytogenet.; (United States) Journal Issue: 3 Vol. 1; ISSN CGCYD
• Country of Publication: United States
• Language: English

Related Subjects

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGY
CELL CULTURES
CHROMOSOMAL ABERRATIONS
CHROMOSOMES
CLONE CELLS
DISEASES
GENETIC EFFECTS
GENETICS
HEMIC DISEASES
KARYOTYPE
LEUKEMIA
MAMMALS
MAN
MUTATIONS
NEOPLASMS
PATHOLOGY
PRIMATES
VERTEBRATES