Chromosomal abnormalities and environmental exposures in acute nonlymphocytic leukemia

Conference · · Archives of Environmental Health; (USA)

OSTI ID:5153113

Crane, M M; Keating, M J; Trujillo, J M; Labarthe, D R ^[1]

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1. Univ. of Texas Health Science Center School of Public Health, Houston (USA)

Chromosomal abnormalities are present in bone marrow of approximately 50% of newly diagnostic acute nonlymphatic leukemia (ANLL) patients, but their etiologic significance, if any, is unclear. The frequency of environmental exposures, gathered by questionnaire from patients or relatives, was compared in 127 newly diagnosed ANLL patients with marrow abnormalities (AA) and 109 ANLL patients with cytogenetically normal marrow. These represented 73% of de novo patients treated at M. D. Anderson Hospital between 1976 and 1983. AA patients were more likely than NN patients to: report cytotoxic treatment for prior medical conditions, smoke cigarettes, drink alcoholic beverages, and work at occupations with possible exposure to mutagens. No statistically significant associations between aneuploidy and use of other tobacco, avocational exposure to chemicals or exposure to animals were present. Associations between specific abnormalities and prior cytotoxic therapy (deletion of chromosome 7), smoking (extra chromosome 8, inversion chromosome 16), and occupation at the time of diagnosis (translocation between chromosomes 8 and 21) were noted. No association between occupational exposure to benzene or ionizing radiation and the 6 most common chromosomal abnormalities in ANLL patients were noted, although these agents are known to be leukemogenic. Problems with interpreting the above associations, including the high nonresponse rate, a high proportion of surrogate respondents, and the large number of significance tests that were performed, are discussed. These results are consistent with those from previously reported series, and suggest that tumor-specific markers may be present for some exposures in this disease.

• OSTI ID: 5153113
• Report Number(s): CONF-8706410--
• Conference Information: Journal Name: Archives of Environmental Health; (USA) Journal Volume: 43:2
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
99 GENERAL AND MISCELLANEOUS
AEROSOLS
ALCOHOLS
ANIMAL TISSUES
AROMATICS
BENZENE
BIOLOGICAL MARKERS
BODY
BONE MARROW
CHEMOTHERAPY
CHROMOSOMAL ABERRATIONS
COLLOIDS
DIAGNOSIS
DISEASES
DISPERSIONS
EPIDEMIOLOGY
ETHANOL
ETIOLOGY
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
HYDROCARBONS
HYDROXY COMPOUNDS
IMMUNE SYSTEM DISEASES
IONIZING RADIATIONS
LEUKEMIA
MUTATIONS
NEOPLASMS
OCCUPATIONAL EXPOSURE
ORGANIC COMPOUNDS
ORGANS
RADIATIONS
RESIDUES
SMOKES
SOLS
THERAPY
TISSUES
TOBACCO SMOKES