Urethane anesthesia blocks the development and expression of kindled seizures

Journal Article · Sat Dec 31 23:00:00 EST 1988 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(89)90315-9· OSTI ID:5900526

Cain, D P; Raithby, A; Corcoran, M E

The effect of anesthetic and subanesthetic doses of urethane on the development of amygdala kindled seizures and on the expression of previously kindled seizures was studied in hooded rats. An anesthetic dose of urethane almost completely eliminated evoked after discharge and completely eliminated convulsive behavior in both groups. It also eliminated the seizure response to pentylenetetrazol. Subanesthetic doses of urethane strongly attenuated the expression of previously kindled seizures. These results suggest that urethane may not be an appropriate anesthetic for the study of epileptiform phenomena.

• Research Organization: Univ. of Western Ontario, London (Canada)
• OSTI ID: 5900526
• Journal Information: Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 44:17; ISSN LIFSA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANESTHESIA
ANIMALS
BIOLOGICAL EFFECTS
BODY
BRAIN
CARBAMATES
CARBONIC ACID DERIVATIVES
CARBOXYLIC ACID SALTS
CENTRAL NERVOUS SYSTEM
MAMMALS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
RATS
RODENTS
URETHANE
VERTEBRATES