Kindled seizures selectively reduce a subpopulation of (/sup 3/H)quinuclidinyl benzilate binding sites in rat dentate gyrus

Journal Article · Wed Sep 01 00:00:00 EDT 1982 · J. Pharmacol. Exp. Ther.; (United States)

OSTI ID:6942442

Savage, D D; McNamara, J O

Amygdala-kindled seizures reduced significantly the total number of (/sup 3/H)quinuclidinyl benzilate binding sites in both dentate and hippocampal gyri compared to electrode implanted unstimulated controls. Both high and low affinity carbachol displaceable binding site populations were significantly reduced in hippocampal gyrus. By contrast, a selective decline of low affinity sites was found in dentate gyrus membranes. The selectivity of the decline in dentate but not hippocampus gyrus underscores the specificity of this molecular response to amygdala-kindled seizures. We suggest that these receptor alterations underlie adaptive mechanisms which antagonize kindled epileptogenesis.

• Research Organization: Department of Pharmacology, Duke University Medical Center, Durham, North Carolina
• OSTI ID: 6942442
• Journal Information: J. Pharmacol. Exp. Ther.; (United States), Journal Name: J. Pharmacol. Exp. Ther.; (United States) Vol. 222:3; ISSN JPETA
• Country of Publication: United States
• Language: English

Related Subjects

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59 BASIC BIOLOGICAL SCIENCES
ANTIHYPERTENSIVE AGENTS
BIOLOGICAL PATHWAYS
BODY
BRAIN
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
DISEASES
DRUGS
EPILEPSY
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
ORGANS
PATHOLOGY
RECEPTORS
TRACER TECHNIQUES
TRITIUM COMPOUNDS