Cysteamine normalizes cerebral somatostatin level and binding in pentylenetetrazol-kindled rats
- Univ. of Alcala de Henares, Madrid (Spain)
Rats were kindled by intraperitoneal injection of pentylenetetrazol (PTZ) every 48 h. Once kindled, some of the animals received a single injection of cysteamine. Somatostatin-like immunoreactivity (SLI) and {sup 125}I-Tyr{sup 11} -somatostatin binding were measured in the frontoparietal cortex and hippocampus of the two experimental groups and the control rats. After PTZ kindling the following was observed: (1) SLI content was increased int he two areas; (2) Somatostatin receptor affinity decreased in the frontoparietal cortex and was unaltered in the hippocampus; (3) The number of somatostatin receptors decreased in the hippocampus and was unaltered in the frontoparietal cortex. Cysteamine, an agent which depletes brain somatostatin and suppresses kindled seizures in PTZ-treated rats, revered the altered SLI levels and binding in these rats.
- OSTI ID:
- 6994816
- Journal Information:
- Life Sciences; (USA), Journal Name: Life Sciences; (USA) Vol. 45:25; ISSN 0024-3205; ISSN LIFSA
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
AFFINITY
AMINES
ANIMALS
BETA DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
BIOSYNTHESIS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CYSTAMINE
DAYS LIVING RADIOISOTOPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTRAPERITONEAL INJECTION
IODINE 125
IODINE ISOTOPES
ISOTOPES
KINETICS
MAMMALS
MEMBRANE PROTEINS
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PROTEINS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RATS
REACTION KINETICS
RECEPTORS
RODENTS
SECRETION
SOMATOSTATIN
SYNTHESIS
VERTEBRATES