Cysteamine normalizes cerebral somatostatin level and binding in pentylenetetrazol-kindled rats

Journal Article · Sun Jan 01 00:00:00 EST 1989 · Life Sciences; (USA)

DOI:https://doi.org/10.1016/0024-3205(89)90010-6· OSTI ID:6994816

Perez-Ozo, E; Lopez-Ruiz, M P; Gonzalez-Guijarro, L; Arilla, E ^[1]

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1. Univ. of Alcala de Henares, Madrid (Spain)

Rats were kindled by intraperitoneal injection of pentylenetetrazol (PTZ) every 48 h. Once kindled, some of the animals received a single injection of cysteamine. Somatostatin-like immunoreactivity (SLI) and {sup 125}I-Tyr{sup 11} -somatostatin binding were measured in the frontoparietal cortex and hippocampus of the two experimental groups and the control rats. After PTZ kindling the following was observed: (1) SLI content was increased int he two areas; (2) Somatostatin receptor affinity decreased in the frontoparietal cortex and was unaltered in the hippocampus; (3) The number of somatostatin receptors decreased in the hippocampus and was unaltered in the frontoparietal cortex. Cysteamine, an agent which depletes brain somatostatin and suppresses kindled seizures in PTZ-treated rats, revered the altered SLI levels and binding in these rats.

• OSTI ID: 6994816
• Journal Information: Life Sciences; (USA), Vol. 45:25; ISSN 0024-3205
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
CYSTAMINE
BIOCHEMICAL REACTION KINETICS
SOMATOSTATIN
BIOSYNTHESIS
AFFINITY
BRAIN
INTRAPERITONEAL INJECTION
IODINE 125
RATS
RECEPTORS
SECRETION
AMINES
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CENTRAL NERVOUS SYSTEM
DAYS LIVING RADIOISOTOPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
KINETICS
MAMMALS
MEMBRANE PROTEINS
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PROTEINS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
REACTION KINETICS
RODENTS
SYNTHESIS
VERTEBRATES
550201* - Biochemistry- Tracer Techniques