Mesolimbic dopaminergic supersensitivity following electrical kindling of the amygdala
Limbic seizures developed in rats following daily electrical stimulation of the basolateral nucleus of the amygdala. Animals were designated as kindled after five complete (stage 5) behavioral seizures were observed. A subgroup, designated as superkindled, received three additional weeks of electrical stimulations. Kindled rats were significantly subsensitive to the stereotypy-inducing effects of apomorphine, a direct dopamine agonist, compared to controls. Superkindled rats were supersensitive to the effects of apomorphine. However, both kindled and superkindled rats demonstrated an increase in /sup 3/H-spiperone Bmax values, reflecting dopamine D2-receptor densities, in the nucleus accumbens ipsilateral to the stimulating electrode. The number of interictal spikes recorded from the stimulating amygdaloid electrode during the last week of kindling was correlated with changes in apomorphine sensitivity in individual animals.
- Research Organization:
- Stanford Univ. School of Medicine, Palo Alto, CA (USA)
- OSTI ID:
- 5346792
- Journal Information:
- Biol. Psychiatry; (United States), Journal Name: Biol. Psychiatry; (United States) Vol. 23:3; ISSN BIPCB
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
CARDIOTONICS
CARDIOVASCULAR AGENTS
CELL CONSTITUENTS
CELL NUCLEI
DOPAMINE
DRUGS
ELECTRIC SHOCK
ELECTRODES
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MEMBRANE PROTEINS
NERVES
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
PHENOLS
POLYPHENOLS
PROTEINS
RATS
RECEPTORS
RODENTS
SPIPERONE
SYMPATHOMIMETICS
THERAPY
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES