Restriction of enhanced (2-/sup 14/C)deoxyglucose utilization to rhinencephalic structures in immature amygdala-kindled rats

Journal Article · Sat Apr 01 04:00:00 EST 1989 · Exp. Neurol.; (United States)

DOI:https://doi.org/10.1016/0014-4886(89)90011-3· OSTI ID:6154449

Ackermann, R F; Moshe, S L; Albala, B J

Sixteen-day-old albino rat pups were kindled to varying degrees of seizure severity with amygdala stimulations spaced 15 to 20 min apart. Subsequently, each rat pup was injected (ip) with 10 microCi of (2-/sup 14/C)-deoxyglucose, and received several additional kindled seizures at regular intervals throughout the following 80 min, at which time it was killed and processed for deoxyglucose autoradiography. Increased seizure severity was associated with correspondingly increased deoxyglucose utilization in many rhinencephalic limbic structures. However, unlike adults, rat pups did not show discernibly increased neocortical, thalamic, or substantia nigra utilization. We postulate that the apparent confinement of seizure activity to limbic structures in pups is related to their relative lack of postictal seizure refractoriness, as well as to other indices of increased seizure susceptibility in immature animals.

• Research Organization: Univ. of California, Los Angeles (USA)
• OSTI ID: 6154449
• Journal Information: Exp. Neurol.; (United States), Journal Name: Exp. Neurol.; (United States) Vol. 104:1; ISSN EXNEA
• Country of Publication: United States
• Language: English

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550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALDEHYDES
ANIMALS
AUTORADIOGRAPHY
BODY
BRAIN
CARBOHYDRATES
CARBON 14 COMPOUNDS
CENTRAL NERVOUS SYSTEM
GLUCOSE
HEXOSES
LABELLED COMPOUNDS
MAMMALS
METABOLISM
MONOSACCHARIDES
NEONATES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
RATS
RODENTS
SACCHARIDES
VERTEBRATES