Endotoxin of Escherichia coli and permeability of the mammary glands of goats

Journal Article · Thu Jan 01 04:00:00 EST 1987 · J. Dairy Sci.; (United States)

DOI:https://doi.org/10.3168/jds.S0022-0302(87)79995-0· OSTI ID:5900112

Lengemann, F W; Pitzrick, M

Serial collections of milk were used to determine where in the mammary gland endotoxin of Escherichia coli was effective in altering the transfer of selected milk components into blood and blood components into milk. Lactating goats had half the gland infused with 1 ..mu..g of endotoxin and the other half served as a control. Sodium-24 and /sup 42/K or (/sup 14/C) lactose were included with /sup 141/Ce in the infusate in some experiments, whereas in others /sup 99m/Tc-labelled albumin or /sup 24/Na and /sup 42/K were given intravenously 2 h after the endotoxin infusion. Milk was collected 3 h after endotoxin infusion. Endotoxin increased the loss of /sup 24/Na, /sup 42/K, and (/sup 14/C) lactose from the mammary gland and increased the transfer of /sup 24/Na and /sup 99m/Tc-albumin into the gland. The transfer in of /sup 42/K was reduced compared with control halves. Movement of stable Na and K was in accord with the movement of the /sup 24/Na and /sup 42/K. Endotoxin was effective in all parts of the gland but particularly from the mid-portion upward to the alveoli. For the control halves there was evidence that some /sup 24/Na and /sup 42/K crossed the ductal or cisternal epithelium into blood outside of the alveoli, whereas only /sup 42/K provided evidence for transfer from blood to milk in these same regions. There was no demonstrable transfer of lactose and albumin in regions other than the alveoli.

• Research Organization: New York State College of Veterinary Medicine, Ithaca
• OSTI ID: 5900112
• Journal Information: J. Dairy Sci.; (United States), Journal Name: J. Dairy Sci.; (United States) Vol. 70:1; ISSN JDSCA
• Country of Publication: United States
• Language: English

Related Subjects

553005* -- Agriculture & Food Technology-- Animal Husbandry-- (1987-)
60 APPLIED LIFE SCIENCES
ALBUMINS
ALKALI METAL ISOTOPES
ANIMALS
ANTIGENS
BACTERIA
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
CARBOHYDRATES
CARBON 14
CARBON ISOTOPES
CERIUM 141
CERIUM ISOTOPES
DAYS LIVING RADIOISOTOPES
DISACCHARIDES
DOMESTIC ANIMALS
ENDOTOXINS
ESCHERICHIA COLI
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
GLANDS
GOATS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LACTOSE
LIGHT NUCLEI
MAMMALS
MAMMARY GLANDS
MATERIALS
MICROORGANISMS
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
OLIGOSACCHARIDES
ORGANIC COMPOUNDS
ORGANS
PERMEABILITY
POTASSIUM 42
POTASSIUM ISOTOPES
PROTEINS
RADIOISOTOPES
RARE EARTH ISOTOPES
RARE EARTH NUCLEI
RUMINANTS
SACCHARIDES
SECONDS LIVING RADIOISOTOPES
SODIUM 24
SODIUM ISOTOPES
TECHNETIUM 99
TECHNETIUM ISOTOPES
TOXIC MATERIALS
TOXINS
TRACER TECHNIQUES
VERTEBRATES
YEARS LIVING RADIOISOTOPES