Effects of endotoxin on mammary secretion of lactating cows. [Escherichia coli]

Journal Article · Thu May 01 04:00:00 EDT 1986 · J. Dairy Sci.; (United States)

DOI:https://doi.org/10.3168/jds.S0022-0302(86)80531-8· OSTI ID:5618106

Lengemann, F W; Pitzrick, M

The objectives were to describe the magnitude and time course of changes in milk pH, Na, K, lactose, and somatic cells and to determine if paracellular pathways were altered after infusion of Escherichia coli endotoxin (serotype 0128:AB12) to produce inflammation in one-half of the udder of the goat. Intramammary infusion of endotoxin increased pH, number of somatic cells, and Na and decreased K and lactose in milk. Sodium and number of somatic cells were increased by as little as .1..mu..g of endotoxin; .25 ..mu..g produced changes in most of the other parameters; maximal effect was elicited by 1..mu..g of endotoxin. The gland response peaked from 5 to 7 h after infusion of endotoxin with an increase in milk cellularity as the only significant effect noted in the control gland. Infusion of (/sup 14/C)lactose into the gland and (/sup 99m/Tc)albumin into the blood demonstrated that large molecules were more able to cross into and out of udder halves after endotoxin treatment. It is suggested that ion interchange rather than bulk flow across paracellular paths is responsible for changes. In addition, endotoxin appeared to reduce lactose secretion and synthesis.

• Research Organization: New York State College of Veterinary Medicine, Ithaca
• OSTI ID: 5618106
• Journal Information: J. Dairy Sci.; (United States), Journal Name: J. Dairy Sci.; (United States) Vol. 69:5; ISSN JDSCA
• Country of Publication: United States
• Language: English

Related Subjects

553001* -- Agriculture & Food Technology-- Tracer Techniques-- (-1987)
60 APPLIED LIFE SCIENCES
ALBUMINS
ALKALI METALS
ANIMALS
ANTIGENS
BACTERIA
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL FUNCTIONS
BIOLOGICAL MATERIALS
BIOLOGICAL PATHWAYS
BODY
BODY FLUIDS
CARBOHYDRATES
CARBON 14 COMPOUNDS
CHEMICAL COMPOSITION
DISACCHARIDES
DOMESTIC ANIMALS
ELEMENTS
ENDOTOXINS
ESCHERICHIA COLI
FOOD
FUNCTIONS
GLANDS
GOATS
HOURS LIVING RADIOISOTOPES
INFLAMMATION
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LACTOSE
MAMMALS
MAMMARY GLANDS
MATERIALS
METALS
MICROORGANISMS
MILK
NUCLEI
ODD-EVEN NUCLEI
OLIGOSACCHARIDES
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PH VALUE
PROTEINS
RADIOISOTOPES
RUMINANTS
SACCHARIDES
SODIUM
SYMPTOMS
TECHNETIUM 99
TECHNETIUM ISOTOPES
TOXIC MATERIALS
TOXINS
TRACER TECHNIQUES
VERTEBRATES
YEARS LIVING RADIOISOTOPES