Suppression by perchlorate of technetium-99m and iodine-123 secretion in milk of lactating goats

Journal Article · Wed Jul 01 04:00:00 EDT 1987 · J. Nucl. Med.; (United States)

OSTI ID:6020845

Mountford, P J; Heap, R B; Hamon, M; Fleet, I R; Coakley, A J

Lactating goats were infused with either technetium-99m (/sup 99m/Tc) or iodine-123 (/sup 123/I) together with chlorine-36 (/sup 36/Cl) through an indwelling catheter previously placed in an external pudic mammary artery. The radioisotope infusions were repeated together with 100 mg of sodium perchlorate. There was a rapid transfer of /sup 99m/Tc and /sup 123/I into milk, reaching a peak concentration 30 min after a 15-min infusion. The fractional secretion of /sup 99m/Tc and /sup 123/I in milk was reduced by 70%-80% and 60%-66%, respectively, by perchlorate. The fractional secretion of /sup 36/Cl was not affected by perchlorate, and the shape of the /sup 36/Cl secretion curve differed from those of /sup 99m/Tc and /sup 123/I, which were similar. It is probable, therefore, that the latter nuclides were secreted by a transport route different from that of chloride. Available data describing the secretion of /sup 99m/Tc in human milk after pertechnetate administration was reviewed, and it was concluded that perchlorate pretreatment significantly reduced the secretion of /sup 99m/Tc in human breast milk.

• Research Organization: Kent and Canterbury Hospital, England
• OSTI ID: 6020845
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 28:7; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CHLORINE 36
CHLORINE ISOTOPES
DOMESTIC ANIMALS
ELECTRON CAPTURE RADIOISOTOPES
FOOD
GLANDS
GOATS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 123
IODINE ISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LACTATION
LIGHT NUCLEI
MAMMALS
MAMMARY GLANDS
MATERIALS
MILK
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANS
OXYGEN COMPOUNDS
PERTECHNETATES
PREGNANCY
RADIOISOTOPES
RADIONUCLIDE KINETICS
REFRACTORY METAL COMPOUNDS
RUMINANTS
TECHNETIUM 99
TECHNETIUM COMPOUNDS
TECHNETIUM ISOTOPES
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
YEARS LIVING RADIOISOTOPES