Intestinal calcium transport: parathyroid hormone and adaptation to dietary calcium

Journal Article · Wed Dec 31 23:00:00 EST 1975 · Arch. Biochem. Biophys.; (United States)

DOI:https://doi.org/10.1016/0003-9861(76)90506-3· OSTI ID:5868853

Ribovich, M L; DeLuca, H F

Thyroparathyroidectomy prevents the elevation of intestinal calcium transport in response to low dietary levels of calcium. Removal of the thyroparathyroid glands reduces elevated intestinal calcium transport of rats on low calcium diets to the levels found in rats fed high calcium diets. This reduction took place 4 days after surgery. The chronic administration of a constant exogenous source of parathyroid hormone to thyroparathyroidectomized rats fed either a high or low calcium diet resulted in high rates of intestinal calcium transport independent of dietary calcium. Since 1,25-dihydroxyvitamin D/sub 3/ supplementation eliminates adaptation in a similar manner, these results strongly support the idea that parathyroid glands mediate intestinal adaptation to low dietary calcium presumably by the stimulation of 1,25-dihydroxyvitamin D/sub 3/ biosynthesis by secreted parathyroid hormone.

• Research Organization: Univ. of Wisconsin, Madison
• OSTI ID: 5868853
• Journal Information: Arch. Biochem. Biophys.; (United States), Journal Name: Arch. Biochem. Biophys.; (United States) Vol. 175; ISSN ABBIA
• Country of Publication: United States
• Language: English

Related Subjects

550200* -- Biochemistry
551000 -- Physiological Systems
59 BASIC BIOLOGICAL SCIENCES
ALKALINE EARTH METALS
BODY
CALCIUM
CHOLECALCIFEROL
DIET
DIGESTIVE SYSTEM
ELEMENTS
ENDOCRINE GLANDS
GASTROINTESTINAL TRACT
GLANDS
HORMONES
INTESTINAL ABSORPTION
INTESTINES
METALS
ORGANS
PARATHORMONE
PARATHYROID GLANDS
PEPTIDE HORMONES
RESPONSE MODIFYING FACTORS
UPTAKE
VITAMIN D
VITAMINS