1,25-dihydroxyvitamin D/sub 3/ metabolism. The effect of dietary calcium and phosphorus

Journal Article · Sun Jan 01 04:00:00 EST 1978 · Arch. Biochem. Biophys.; (United States)

DOI:https://doi.org/10.1016/0003-9861(78)90369-7· OSTI ID:5704783

Ribovich, M L; DeLuca, H F

Rats maintained on tritiated 1,25-dihydroxyvitamin D/sub 3/ as their sole source of vitamin D and placed on diets differing in calcium content had similar intestinal levels of tritiated 1,25-dihydroxyvitamin D/sub 3/. Since 1,25-dihydroxyvitamin D/sub 3/ administration eliminated adaptation of intestinal calcium transport, it appears that increased production of 1,25-dihydroxyvitamin D/sub 3/ is responsible for the stimulation of calcium transport by low dietary calcium. When maintained on tritiated, 1,25-dihydroxyvitamin D/sub 3/, rats fed a low-phosphorus diet had somewhat higher levels of tritiated 1,25-dihydroxyvitamin D/sub 3/ in the duodenum and plasma than rats on a normal-phosphorus diet. In addition to stimulating 1,25-dihydroxyvitamin D/sub 3/ synthesis, low dietary phosphorus may increase the accumulation of 1,25-dihydroxyvitamin D/sub 3/ in both intestine and plasma.

• Research Organization: Univ. of Wisconsin, Madison
• OSTI ID: 5704783
• Journal Information: Arch. Biochem. Biophys.; (United States), Journal Name: Arch. Biochem. Biophys.; (United States) Vol. 188:1; ISSN ABBIA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
ALKALINE EARTH METALS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL FUNCTIONS
CALCIUM
CHOLECALCIFEROL
DIET
ELEMENTS
HYDROGEN ISOTOPES
INTESTINAL ABSORPTION
ISOTOPES
LIGHT NUCLEI
MAMMALS
METABOLISM
METALS
NONMETALS
NUCLEI
ODD-EVEN NUCLEI
PHOSPHORUS
RADIOISOTOPES
RATS
RESPONSE MODIFYING FACTORS
RODENTS
TRITIUM
UPTAKE
VERTEBRATES
VITAMIN D
VITAMINS
YEARS LIVING RADIOISOTOPES