Influence of dietary calcium and phosphorus on intestinal calcium transport in rats given vitamin D metabolites

Journal Article · Wed Jan 01 04:00:00 EST 1975 · Arch. Biochem. Biophys.; (United States)

DOI:https://doi.org/10.1016/0003-9861(75)90148-4· OSTI ID:7256587

Ribovich, M L; DeLuca, H F

The stimulation of intestinal calcium transport by a low calcium diet has been compared to that produced by a low phosphorus diet in rats given vitamin D/sub 3/, 25-hydroxyvitamin D/sub 3/ or 1,25-dihydroxyvitamin D/sub 3/. The administration of 1,25-dihydroxyvitamin D/sub 3/ eliminates the effect of low calcium diets but does not eliminate the effect of low phosphorus diets. The daily administration of large doses of vitamin D/sub 3/ or 25-hydroxyvitamin D/sub 3/ also eliminates the stimulation by low calcium diets but does not eliminate the stimulation by low phosphorus diets. These results suggest that in addition to stimulating 1,25-dihydroxyvitamin D/sub 3/ synthesis, low phosphorus diets must have some other unknown effect on intestinal calcium transport. The data are, however, consistent with the idea that the stimulation of intestinal calcium transport by low dietary calcium is the direct consequence of increased 1,25-dihydroxyvitamin D/sub 3/ synthesis.

• Research Organization: Univ. of Wisconsin, Madison
• OSTI ID: 7256587
• Journal Information: Arch. Biochem. Biophys.; (United States), Journal Name: Arch. Biochem. Biophys.; (United States) Vol. 170; ISSN ABBIA
• Country of Publication: United States
• Language: English

Related Subjects

550200 -- Biochemistry
550500* -- Metabolism
59 BASIC BIOLOGICAL SCIENCES
ALKALINE EARTH METALS
ANIMALS
BIOLOGICAL EFFECTS
BODY
CALCIUM
CHOLECALCIFEROL
DIET
DIGESTIVE SYSTEM
ELEMENTS
GASTROINTESTINAL TRACT
INTESTINES
MAMMALS
METABOLISM
METALS
NONMETALS
ORGANS
PHOSPHORUS
RATS
RODENTS
VERTEBRATES
VITAMIN D
VITAMINS