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Quantitative measurement of regional pulmonary blood flow with positron emission tomography

Journal Article · · J. Appl. Physiol.; (United States)
OSTI ID:5860477
; ; ; ;
We have measured regional pulmonary blood flow (PBF) in normal dogs with positron emission tomography (PET) and 15O-labeled water (H2(15)O). The method is nondestructive, quantitative, and repeatable. To measure PBF, PET is used to measure both the initial and equilibrium distribution of lung activity after H2(15)O infusion. The data are then interpreted with a one-compartment mathematical model. Measurements of PBF in dogs with H2(15)O (PBF-water) were compared with PBF measured with 68Ga microspheres (PBF-MS), and a close correlation was observed: PBF-water = 0.82 PBF-MS + 25.4 (R = 0.97, n = 52). In another set of animals an important assumption of the method, namely that the tracer is fully extracted during a single pass through the lung, was demonstrated using a single-probe residue-detection technique. Computer simulations were performed to illustrate the sensitivity of the method to errors in the measured variables of tracer activity or tissue-blood partition coefficient. Results showed only small error magnification for the range of values observed in these studies.
Research Organization:
Washington Univ. School of Medicine, St. Louis, MO
OSTI ID:
5860477
Journal Information:
J. Appl. Physiol.; (United States), Journal Name: J. Appl. Physiol.; (United States) Vol. 1; ISSN JAPYA
Country of Publication:
United States
Language:
English

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Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BLOOD FLOW
BODY
COMPARATIVE EVALUATIONS
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DOGS
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
GALLIUM 68
GALLIUM ISOTOPES
HOURS LIVING RADIOISOTOPES
HYDROGEN COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
LUNGS
MAMMALS
MEASURING METHODS
MICROSPHERES
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
ORGANS
OXYGEN 15
OXYGEN COMPOUNDS
OXYGEN ISOTOPES
POSITRON COMPUTED TOMOGRAPHY
RADIOISOTOPES
RESPIRATORY SYSTEM
SENSITIVITY
TOMOGRAPHY
VERTEBRATES
WATER