The measurement of regional pulmonary blood flow using positron emission tomography and O-15 water

Conference · Wed May 01 04:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:5958343

Mintun, M A; Marklin, G F; Green, M A; Schuster, D P

The authors developed and validated a method for the in vivo quantitative measurement of regional pulmonary blood flow (PBF) using O-15 water (Tl/2 = 123 sec) and positron emission tomography (PET). The method, as implemented in supine dogs, involved a 20 sec constant infusion of approximately 50 mCi of O-15 water through a central venous catheter with concommitant collection of a 15 sec PET scan of the dog chest and sampling of blood activity through a pulmonary artery catheter. These data are interpreted using an adaptation of the technique to measure cerebral blood flow. To validate their method, the authors correlated PBF obtained with O-15 water (PBF-H/sub 2/O) with the regional PBF measured with Ga-68 microspheres (PBF-MS) using PET and standard microsphere techniques at normal cardiac output (CO) mean = 108 ml/min/kg), and low CO (mean = 51 ml/min/kg). The authors conclude that for the investigation of many pathological lung states associated with normal to low CO this method provides an accurate, quantitative, and repeatable measure of regional lung perfusion.

• Research Organization: Washington Univ. School of Medicine, St. Louis, MO
• OSTI ID: 5958343
• Report Number(s): CONF-850611-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 26:5
• Country of Publication: United States
• Language: English

Related Subjects

550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ACCURACY
ANIMALS
ARTERIES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BLOOD FLOW
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
COMPUTERIZED TOMOGRAPHY
CORONARIES
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DOGS
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
HYDROGEN COMPOUNDS
IMAGE PROCESSING
IN VIVO
INJECTION
INTAKE
INTRAVENOUS INJECTION
ISOTOPES
LIGHT NUCLEI
LUNGS
MAMMALS
MICROSPHERES
MINUTES LIVING RADIOISOTOPES
NUCLEI
ORGANS
OXYGEN 15
OXYGEN COMPOUNDS
OXYGEN ISOTOPES
POSITRON COMPUTED TOMOGRAPHY
PROCESSING
RADIOISOTOPE SCANNING
RADIOISOTOPES
RESPIRATORY SYSTEM
TOMOGRAPHY
VERTEBRATES
WATER