Quantification of regional myocardial blood flow in vivo with H/sub 2//sup 15/O. [Dogs]

Journal Article · Mon Oct 01 04:00:00 EDT 1984 · Circulation; (United States)

DOI:https://doi.org/10.1161/01.CIR.70.4.724· OSTI ID:5779100

Bergmann, S R; Fox, K A; Rand, A L; McElvany, K D; Welch, M J; Markham, J; Sobel, B E

Using H/sub 2//sup 15/O the authors demonstrated that a modification of the tissue autoradiographic approach permitted quantitation of myocardial blood flow in open-chest dogs by direct assay of myocardial tissue and that noninvasive estimation with positron-emission tomography (PET) delineated relative myocardial blood flow in intact dogs. In open-chest anesthetized dogs, the single-pass extraction fraction of H/sub 2//sup 15/O averaged 96 +/- 5% at flows of 80 to 100 ml/100 g/min. Myocardial blood flow calculated after a 60 sec intravenous infusion of H/sub 2//sup 15/O and direct analysis of tissue correlated well with results obtained with microspheres. Subsequently the approach was adapted for preliminary use with PET. Tomograms obtained in vivo in six dogs with either normal or reduced regional blood flow correlated closely with the tomographically detectable distribution of /sup 68/Ga-labeled microspheres and with postmortem microsphere distribution. The technique accurately reflects myocardial blood flow. With the use of PET, rapid sequential noninvasive estimation of relative regional myocardial blood flow has been demonstrated that should ultimately permit improved objective assessment of nutritional blood flow in patients in response to medical and surgical interventions designed to augment perfusion.

• Research Organization: Washington Univ. School of Medicine, St. Louis, MO
• OSTI ID: 5779100
• Journal Information: Circulation; (United States), Journal Name: Circulation; (United States) Vol. 70:4; ISSN CIRCA
• Country of Publication: United States
• Language: English

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550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
AUTORADIOGRAPHY
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BLOOD FLOW
BODY
CARDIOVASCULAR SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DOGS
DYNAMIC FUNCTION STUDIES
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
GALLIUM 68
GALLIUM ISOTOPES
HEART
HOURS LIVING RADIOISOTOPES
HYDROGEN COMPOUNDS
IN VIVO
INTERMEDIATE MASS NUCLEI
ISOTOPES
LIGHT NUCLEI
MAMMALS
MICROSPHERES
MINUTES LIVING RADIOISOTOPES
MUSCLES
MYOCARDIUM
NUCLEI
ODD-ODD NUCLEI
ORGANS
OXYGEN 15
OXYGEN COMPOUNDS
OXYGEN ISOTOPES
POSITRON COMPUTED TOMOGRAPHY
RADIOISOTOPES
TOMOGRAPHY
VERTEBRATES
WATER