Effect of regional myocardial ischemia on sympathetic nervous system as assessed by fluorine-18-metaraminol

Journal Article · Wed Aug 01 04:00:00 EDT 1990 · Journal of Nuclear Medicine; (USA)

OSTI ID:6620365

Schwaiger, M; Guibourg, H; Rosenspire, K; McClanahan, T; Gallagher, K; Hutchins, G; Wieland, D M ^[1]

---

1. Univ. of Michigan Medical Center, Ann Arbor (USA)

With the introduction of radiolabeled catecholamine analogues, the noninvasive evaluation of the cardiac sympathetic nervous system has become possible. This study evaluated the effect of regional ischemia on myocardial retention of the new norepinephrine analogue 6-({sup 18}F) fluorometaraminol (FMR) in the open chest dog model. Six dogs were injected intravenously with FMR following 30-min occlusion of the left anterior descending artery. Six sham animals served as control group. Regional myocardial blood flow as determined by microspheres decreased 87% during ischemia (p less than 0.01), but was not significantly different from control myocardium following reperfusion. Regional myocardial 18F activity as determined postmortem was significantly reduced in reperfused myocardium (-34%), which paralleled an 18% reduction of tissue norepinephrine concentration. Thus, short time periods of coronary occlusion affect neuronal function indicating the sensitivity of the sympathetic nerve terminals to ischemia. FMR provides a new tracer approach for the characterization of neuronal integrity in postischemic myocardium.

• OSTI ID: 6620365
• Journal Information: Journal of Nuclear Medicine; (USA), Journal Name: Journal of Nuclear Medicine; (USA) Vol. 31:8; ISSN 0161-5505; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
AUTONOMIC NERVOUS SYSTEM
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BLOOD FLOW
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
DISEASES
DOGS
DRUGS
FLUORINE 18
FLUORINE ISOTOPES
HEART
HOURS LIVING RADIOISOTOPES
INJECTION
INTAKE
INTRAVENOUS INJECTION
ISCHEMIA
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
METABOLISM
MICROSPHERES
MUSCLES
MYOCARDIUM
NERVOUS SYSTEM
NUCLEI
ODD-ODD NUCLEI
ORGANS
RADIOISOTOPES
RADIOPHARMACEUTICALS
RETENTION
SENSITIVITY
VASCULAR DISEASES
VERTEBRATES