Changes in myocardial blood flow and S-T segment elevation following coronary artery occlusion in dogs

Journal Article · Sun Jun 01 04:00:00 EDT 1975 · Circ. Res., v. 36, no. 6, pp. 697-705

DOI:https://doi.org/10.1161/01.RES.36.6.697· OSTI ID:4088340

Smith, H J; Singh, B N; Norris, R M; John, M B; Hurley, P J

The relationship between regional blood flow and epicardial S-T segment elevation was studied in 26 open-chest anesthetized dogs with left anterior coronary artery ligations. Changes in myocardial blood flow, measured with 15 +- 5 $mu$ (diameter) microspheres labeled with $sup 141$Ce, $sup 85$Sr, and $sup 169$Yb, were correlated with summated S-T segment elevations 15 minutes, 1 hour, and 2 hours after coronary artery occlusion. In normal areas, myocardial blood flow was 113 +- 5 ml/min 100 g$sup -1$ and summated S-T segment elevation was 0.3 +- 0.2 mv. Fifteen minutes after coronary artery occlusion in 26 dogs, S-T segment elevation was 5.7 +- 0.7 mv over the center of the infarct and myocardial blood flow was 10 +- 1 ml/min 100 g$sup -1$; over the border zone, myocardial blood flow was 63 +- 4 ml/min 100 g$sup -1$ and S-T segment elevation was 3.1 +- 0.1 mv. One third of the areas with a myocardial blood flow of 10 ml/min 100 g$sup -1$ or less had no S-T segment elevation. In the center and border zones of the infarct in 9 dogs, myocardial blood flow increased from 11 +- 2 and 67 +- 8 ml/min 100 g$sup -1$ 15 minutes after occlusion to 20 +- 4 and 84 +- 12 ml/min 100 g$sup -1$, respectively, 2 hours after coronary artery occlusion. These increases were not associated with a significant reduction in summated S-T segment elevation. The results do not suggest a simple quantitative relationship between epicardial S-T segment elevation and myocardial blood flow following acute coronary artery occlusion. (auth)

• Research Organization: Michigan State Univ., East Lansing
• NSA Number: NSA-33-020596
• OSTI ID: 4088340
• Journal Information: Circ. Res., v. 36, no. 6, pp. 697-705, Journal Name: Circ. Res., v. 36, no. 6, pp. 697-705; ISSN CIRUA
• Country of Publication: United States
• Language: English

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