Regional myocardial blood flow during acute myocardial infarction in the conscious dog

Journal Article · Sat May 01 04:00:00 EDT 1976 · Circ. Res.; (United States)

DOI:https://doi.org/10.1161/01.RES.38.5.429· OSTI ID:7118440

Bishop, S P; White, F C; Bloor, C M

Regional myocardial blood flow was studied in the conscious dog at periods of 5 minutes to 4 days after occlusion of a major branch of the left coronary artery. Dogs were instrumented with aortic electromagnetic flow probes, occlusive cuffs on either the anterior descending or circumflex branch of the left coronary artery, and a left atrial Silastic catheter for injection of microspheres (15 = 5 ..mu..m) labeled with either /sup 85/Sr, /sup 141/Ce, or /sup 51/Cr. Microspheres were injected into 25 fully conscious dogs during three of the following time periods; control preocclusion and 0.1, 2, 6, 24, or 96 hours postocclusion. In the conscious dog, before occlusion, the endocardial half of the left ventricular myocardium received 28% more blood flow than the epicardial half. After sudden occlusion of a coronary artery branch, there was a marked reduction in blood flow as well as an alteration in distribution of blood flow within the ischemic tissue; blood flow was most severely reduced in the subendocardial center of the ischemic region, less so in the epicardial ischemic region, and least reduced in the marginal region of the infarct. Blood flow was increased to the nonischemic tissue. There was no change in this pattern of reduced blood flow by 6 hours postocclusion, but by 24 hours, flow was moderately increased to all areas except the central subendocardial core, and was further increased at 96 hours. Blood flow to the endocardial half of the left ventricular myocardium averaged 63 ml/100 g per min during the control period, was reduced to 12-18 ml/100 g per min at 0.1-6 hours in the ischemic region, increased to 29 ml/100 g per min at 24 hours, and to 48 ml/100 g per min by 96 hours.

• Research Organization: Univ. of California, San Diego, La Jolla
• OSTI ID: 7118440
• Journal Information: Circ. Res.; (United States), Journal Name: Circ. Res.; (United States) Vol. 38:5; ISSN CIRUA
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
ALKALINE EARTH ISOTOPES
ANIMALS
ARTERIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
BLOOD VESSELS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CERIUM 141
CERIUM ISOTOPES
CHROMIUM 51
CHROMIUM ISOTOPES
DAYS LIVING RADIOISOTOPES
DISEASES
DOGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
HEART
HOURS LIVING RADIOISOTOPES
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MEASURING METHODS
MICROSPHERES
MUSCLES
MYOCARDIAL INFARCTION
MYOCARDIUM
NUCLEI
ORGANS
RADIOISOTOPES
RARE EARTH ISOTOPES
RARE EARTH NUCLEI
STRONTIUM 85
STRONTIUM ISOTOPES
VERTEBRATES