Effects of reestablishing blood flow on extent of myocardial infarction in conscious dogs

Journal Article · Tue Oct 01 04:00:00 EDT 1985 · Am. J. Physiol.; (United States)

OSTI ID:6181256

Murdock, Jr, R H; Chu, A; Grubb, M; Cobb, F R

The effects of permanent circumflex coronary artery occlusion (PO) compared with reestablishing blood flow (OR) at 2 and 6 h after occlusion on the final extent of histological infarction (HI) was assessed in chronically instrumented awake dogs. The relationships between the extent of left ventricular ischemia measured by microsphere techniques and HI in the PO group were used as models to predict the expected infarction in the 2- and 6-h OR groups. Mean HI (+/-SD) in the PO and 6- and 2-h OR groups were not significantly different. The extent of HI in samples grouped according to epicardial and endocardial layers and ischemic blood flow ranges was reduced in the 2-h but not 6-h OR group. Analysis of individual animals using total ischemic region blood flow to epicardial and endocardial layers demonstrated that OR at 2 h but not 6 h reduced infarction in most animals but not in certain animals with the largest ischemic regions.

• Research Organization: Duke Medical Center, Durham, NC
• OSTI ID: 6181256
• Journal Information: Am. J. Physiol.; (United States), Journal Name: Am. J. Physiol.; (United States); ISSN AJPHA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BLOOD FLOW
BLOOD PRESSURE
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
DIAGNOSIS
DISEASES
DOGS
DYNAMIC FUNCTION STUDIES
HEART
ISCHEMIA
ISOTOPES
MAMMALS
MICROSPHERES
MUSCLES
MYOCARDIAL INFARCTION
MYOCARDIUM
ORGANS
RADIOISOTOPES
VASCULAR DISEASES
VERTEBRATES