Evaluation of methods for the quantification of experimental myocardial infarction
Several invasive and noninvasive techniques used in determining the size of experimental myocardial infarction were evaluated after acute ligation of the left anterior descending (LAD) coronary artery in ten dogs. Systemic blood pressure, left ventricular end-diastolic pressure (LVEDP), and heart rate did not change significantly for up to 24 hours after coronary occlusion. Left ventricular wall motion abnormalities were detected by left ventriculography in the distribution of the LAD but these changes did not correlate well with the infarct weight determined at autopsy. On the other hand, the number of epicardial sites with ST-segment elevation of equal to or greater than 2 mm (mean 15.1 sites +- 0.6 SEM) and the infarct area as measured by /sup 99m/Tc-glucoheptonate (TcGH) myocardial imaging (15.7 sq cm +- 0.6) did correlate strongly with the infarct weight (16.8 g +- 0.7) determined by the nitroblue tetrazolium (NBT) technique (r = 0.91). TcGH myocardial scintigaphy and epicardial ST-segment mapping allowed early and accurate quantification of experimental myocardial infarcts ranging from <1 g to 28 g.
- Research Organization:
- New York Hospital-Cornell Medical Center, Ithaca
- OSTI ID:
- 5115373
- Journal Information:
- Circulation; (United States), Journal Name: Circulation; (United States) Vol. 57:1; ISSN CIRCA
- Country of Publication:
- United States
- Language:
- English
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ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
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CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
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DOGS
HEART
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INTERMEDIATE MASS NUCLEI
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ISOMERIC TRANSITION ISOTOPES
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MAMMALS
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ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
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SCINTISCANNING
TECHNETIUM 99
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES