Regional pulmonary distribution of iodine-125-labeled oleic acid. Its relationship to the pattern of oleic acid edema and pulmonary blood flow

Journal Article · Sat Feb 01 04:00:00 EST 1986 · Invest. Radiol.; (United States)

DOI:https://doi.org/10.1097/00004424-198602000-00004· OSTI ID:5614477

Tarver, R D; Tsai, J; Hedlund, L W; Sullivan, D C; Lischko, M M; Harris, C C; Effmann, E L; Putman, C E

Oleic acid infusion in dogs produces a patchy, predominantly peripheral lesion on CT scans. This study correlates the pattern of oleic acid injury with the distribution of infused oleic acid and pulmonary blood flow. Radiolabeled oleic acid (I-125, 0.05 ml/kg) and radiolabeled 15-micron microspheres (Co-57) were infused into the right atria of 11 dogs. Oleic acid was given after the microspheres in six dogs and before microspheres in five dogs. Ten minutes after infusion, the lungs were removed. Four transverse slices (0.5 cm thick) of the lower lobes were taken from each dog and cubed. Samples were grouped into three regions of the transverse slice: outer, middle, and inner concentric rings. In both groups, I-125 (oleic acid) activity was greater in the outer than the middle and inner concentric layers (P less than 0.001). When Cobalt-57 microspheres were given before oleic acid, Cobalt-57 activity was marginally lower in the outer layer compared with the middle and inner layers. However, when oleic acid was given first, microsphere activity in the outer layer was significantly lower (P less than 0.001) than the middle layer. Thus, oleic acid was preferentially distributed to the peripheral regions of the lung, similar to the regions of injury on CT. This distribution did not correspond to the pattern of pulmonary blood flow as indicated by the microspheres. Immediately after oleic acid infusion, pulmonary blood flow to the periphery was reduced, reflecting a response to the predominantly peripheral injury by oleic acid.

• Research Organization: Duke Univ. Medical Center, Durham, NC
• OSTI ID: 5614477
• Journal Information: Invest. Radiol.; (United States), Journal Name: Invest. Radiol.; (United States) Vol. 2; ISSN INVRA
• Country of Publication: United States
• Language: English

Related Subjects

550501 -- Metabolism-- Tracer Techniques
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BLOOD FLOW
BODY
CARBOXYLIC ACIDS
COBALT 57
COBALT ISOTOPES
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
DOGS
EDEMA
ELECTRON CAPTURE RADIOISOTOPES
HISTOLOGICAL TECHNIQUES
INJURIES
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LUNGS
MAMMALS
MICROSPHERES
MONOCARBOXYLIC ACIDS
NUCLEI
ODD-EVEN NUCLEI
OLEIC ACID
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
RADIOISOTOPES
RESPIRATORY SYSTEM
SYMPTOMS
TISSUE DISTRIBUTION
VERTEBRATES