Noninvasive estimation of pulmonary arterial pressure by analysis of pulmonary blood-flow distribution. [Dogs]
Journal Article
·
· J. Nucl. Med.; (United States)
OSTI ID:5831430
To determine whether a correlation exists between pulmonary arterial (PA) pressure (P/sub a/) and the distribution of pulmonary blood flow, this distribution was measured in four upright dogs in the control state and during intravenous infusions of epinephrine or prostaglandin F/sub 2..cap alpha../. During suspension of respiration, 15 mCi of Xe-133 were injected intravenously, and perfusion and equilibration lung images were recorded with a scintillation camera. The procedure was performed several times on each dog, with and without pharmacological elevation of PA pressure by 5 to 50 cm H/sub 2/O. For each scintigram, the relative blood flow per unit ventilated lung volume (F) was plotted against centimeters above the hilum (h). Pulmonary arterial pressure was derived from each curve, assuming the relation F = B(P/sub a/ - hD)/sup 2/, where B = constant and D = specific gravity of blood. Calculated PA pressure correlated strongly (r = 0.83) with measured PA pressure, suggesting a possible means of noninvasive estimation of PA pressure.
- Research Organization:
- Massachusetts General Hospital, Boston
- OSTI ID:
- 5831430
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 20:9; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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·
OSTI ID:5761090
Related Subjects
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ADRENAL HORMONES
ADRENALINE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
BLOOD PRESSURE
BODY
COUNTING TECHNIQUES
DATA
DATA FORMS
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DOGS
DRUGS
EVEN-ODD NUCLEI
EXPERIMENTAL DATA
HORMONES
INFORMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOLATED VALUES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LUNGS
MAMMALS
MEASURING METHODS
NUCLEI
NUMERICAL DATA
ORGANS
PROSTAGLANDINS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RESPIRATORY SYSTEM
SCINTISCANNING
STEROID HORMONES
SYMPATHOMIMETICS
VERTEBRATES
XENON 133
XENON ISOTOPES
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ADRENAL HORMONES
ADRENALINE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
BLOOD PRESSURE
BODY
COUNTING TECHNIQUES
DATA
DATA FORMS
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DOGS
DRUGS
EVEN-ODD NUCLEI
EXPERIMENTAL DATA
HORMONES
INFORMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOLATED VALUES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LUNGS
MAMMALS
MEASURING METHODS
NUCLEI
NUMERICAL DATA
ORGANS
PROSTAGLANDINS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RESPIRATORY SYSTEM
SCINTISCANNING
STEROID HORMONES
SYMPATHOMIMETICS
VERTEBRATES
XENON 133
XENON ISOTOPES