Preparation of tritium multilabelled prostacycline, 6-ketoprostaglandind f/sub 1/alpha// and their methyl esters

Journal Article · Sat Dec 31 23:00:00 EST 1988 · Sov. Radiochem. (Engl. Transl.); (United States)

OSTI ID:5830169

Shevchenko, V P; Lazurkina, T Yu; Pen'ya, A T; Nagaev, I Yu; Myasoedov, N F

Prostacycline, 6-ketoprostaglandin F/sub 1/alpha// and their methyl esters multilabelled by tritium were synthesized. The starting material was the methyl ester of prostaglandin F/sub 2/alpha// with a molar radioactivity of 5.3 TBq/mmole. The yield of methyl ester of prostacycline was 43%, and the molar radioactivity 4.5 TBq/mmole; the yield of methyl ester of 6-ketoprostaglandin F/sub 1/alpha// was 80% (based on methyl ester of prostacycline) with a molar radioactivity of 4.4 TBq/mmole. The sodium salts of prostacycline and 6-ketoprostaglandin F/sub 1/alpha// were obtained by alkaline treatment in a yield of 98-99%.

• OSTI ID: 5830169
• Journal Information: Sov. Radiochem. (Engl. Transl.); (United States), Journal Name: Sov. Radiochem. (Engl. Transl.); (United States) Vol. 30:3; ISSN SVRDA
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400101 -- Activation
Nuclear Reaction
Radiometric & Radiochemical Procedures
400202* -- Isotope Effects
Isotope Exchange
& Isotope Separation
ACETONE
CARBOXYLIC ACID ESTERS
CHEMICAL ANALYSIS
CHEMICAL PREPARATION
CHEMICAL REACTION YIELD
CHEMICAL REACTIONS
CHLORINATED ALIPHATIC HYDROCARBONS
CHLOROFORM
CHROMATOGRAPHY
COUNTING TECHNIQUES
ESTERS
HALOGENATED ALIPHATIC HYDROCARBONS
HYDROGEN COMPOUNDS
INORGANIC ACIDS
KETONES
LABELLED COMPOUNDS
LABELLING
MOLYBDENUM COMPOUNDS
MOLYBDOPHOSPHORIC ACID
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC SOLVENTS
OXYGEN COMPOUNDS
PHOSPHORUS COMPOUNDS
PROSTAGLANDINS
QUANTITATIVE CHEMICAL ANALYSIS
RADIOACTIVITY
RADIOCHEMICAL ANALYSIS
REDUCTION
REFRACTORY METAL COMPOUNDS
SCINTILLATION COUNTING
SEPARATION PROCESSES
SOLVENTS
STABILITY
SYNTHESIS
THIN-LAYER CHROMATOGRAPHY
TRANSITION ELEMENT COMPOUNDS
TRITIUM COMPOUNDS
YIELDS