Mapping of the genes encoding mouse prostaglandin D, E, and F and prostacyclin receptors
- Banyu Tsukuba Research Inst. (Merck), Tsukuba (Japan); and others
Prostaglandins and prostacyclin are metabolites of arachidonic acid and exert a variety of actions to maintain local homeostasis in the body. Their actions are mediated by cell surface receptors specific to the respective ligands. Using a panel of interspecific back-cross mice, we have mapped the prostaglandin D receptor gene (Ptgdr), prostaglandin E receptor subtype EP{sub 1} gene (Ptgerep1), prostaglandin F receptor gene (Ptgfr), and prostacyclin receptor gene (Ptgir). Ptgdr mapped to proximal Chr 14, Ptgfr mapped to distal Chr 3, Ptgerep1 mapped to middle Chr 8, and Ptgir mapped to proximal Chr 7. 50 refs., 1 fig., 1 tab.
- OSTI ID:
- 466605
- Journal Information:
- Genomics, Journal Name: Genomics Journal Issue: 2 Vol. 32; ISSN 0888-7543; ISSN GNMCEP
- Country of Publication:
- United States
- Language:
- English
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