Inorganic and organic selenium toxicosis in young swine: comparison of pathologic changes with those in swine with vitamin E-selenium deficiency

Journal Article · Mon Oct 01 04:00:00 EDT 1973 · Am. J. Vet. Res.; (United States)

OSTI ID:5824439

Herigstad, R R; Whitehair, C K; Olson, O E

Experiments involving 44 pigs were conducted to determine the toxicity of sodium selenite and selenomethionine and to compare clinical signs, lesions, and tissue residues produced by both selenium compounds with those produced by vitamin E-selenium deficiency. Pulmonary edema was the main lesion in swine given sodium selenite. The lesions of selenosis were similar for swine given both selenium compounds and included fatty metamorphosis and centrilobular necrosis in liver; congestion of renal medulla; necrosis in lymphoid folicles; edema and degenerative changes in cerebrum, cerebellum, and spinal cord; edema and hemorrhagic necrosis of adrenal cortex; serous atrophy of body fat; and degenerative changes in diaphragm and skeletal muscles. The lesions of hepatosis dietetica (vitamin E-selenium deficiency) were multifocal lobules of massive hepatic necrosis and intralobular hemorrhage. Generally, pigs with toxicosis had greater concentrations of selenium in liver than in kidney, and those not developing toxicosis had greater concentrations in kidney than in liver.

• Research Organization: Michigan State Univ., East Lansing
• OSTI ID: 5824439
• Journal Information: Am. J. Vet. Res.; (United States), Journal Name: Am. J. Vet. Res.; (United States) Vol. 34; ISSN AJVRA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL COMPOUNDS
ANIMALS
BODY
COMPARATIVE EVALUATIONS
DIGESTIVE SYSTEM
DISTRIBUTION
DOMESTIC ANIMALS
ELEMENTS
GLANDS
INGESTION
INTAKE
KIDNEYS
LIVER
MAMMALS
NUTRITIONAL DEFICIENCY
ORGANS
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
SELENITES
SELENIUM
SELENIUM COMPOUNDS
SEMIMETALS
SODIUM COMPOUNDS
SWINE
SYMPTOMS
TISSUE DISTRIBUTION
TOXICITY
VERTEBRATES
VITAMIN E
VITAMINS