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Effects of single intramuscular injections of selenium at various levels to young swine

Journal Article · · J. Anim. Sci.; (United States)
OSTI ID:6294962
; ;
An experiment involving 33 pigs initially weighing 18 kg, was conducted to investigate the effects of a single intramuscular injection of the effects of a single intramuscular injection of selenium (sodium selenite) at different levels on resulting blood and tissue selenium concentrations at various time intervals post-injection and to determine the effect of a single lethal injectable dosage of selenium. Serum samples were collected and analyzed for SGOT and selenium. Hepatic, kidneys and longissimus muscle tissues were collected and analyzed for selenium. The same tissues were collected from those pigs dying of selenosis. Pigs receiving selenium injections of 1.65 to 3.30 mg/kg BW died of selenosis within 4 hr to 6 days with death occurring earlier at the higher dosage levels. Symptoms in order of occurrence were: vomiting, blind staggers, foaming at the mouth, dyspnea, prostration and death. Elevated SGOT activity was observed in the remaining injected pigs at 12 hr post-injection with the enzyme activity increasing as the dosage quantity increased, suggesting mild selenium toxicosis of body tissues.
Research Organization:
Ohio State Univ., Columbus
OSTI ID:
6294962
Journal Information:
J. Anim. Sci.; (United States), Journal Name: J. Anim. Sci.; (United States) Vol. 40:5; ISSN JANSA
Country of Publication:
United States
Language:
English

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Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
DISTRIBUTION
DOMESTIC ANIMALS
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
ENZYME ACTIVITY
INJECTION
INTAKE
INTRAMUSCULAR INJECTION
KIDNEYS
MAMMALS
MATERIALS
MUSCLES
ORGANS
SELENIUM
SEMIMETALS
SINGLE INTAKE
SWINE
SYMPTOMS
TISSUE DISTRIBUTION
TOXICITY
VERTEBRATES