Acute selenium toxicosis induced in baby pigs by parenteral administration of selenium-vitamin E preparations

Journal Article · Sun Sep 15 04:00:00 EDT 1974 · J. Am. Vet. Med. Assoc.; (United States)

OSTI ID:6498006

Van Vleet, J F; Meyer, K B; Olander, H J

Acute selenium (Se) toxicosis was induced in baby pigs by intramuscular (IM) injection of Se, as selenite, using commercially available selenium-vitamin E (Se-E) preparations. Graded amounts of Se were given to 26 pigs from a herd that had not experienced losses from Se-E deficiency and to 136 pigs from a herd that had continual losses from Se-E deficiency. Of the 2 groups of pigs, those from the Se-E-deficient herd were more susceptible to acute Se toxicosis. Clinical signs of toxicosis were vomiting, anorexia, depression, dyspnea, weakness, and coma, with death occurring 24 to 48 hours after injection. Pathologic alterations observed grossly and histologically included pulmonary edema, skeletal myodegeneration, hepatic degeneration and necrosis, transudation into body cavities, and widespread circulatory disturbances. Mean tissue Se concentrations in 20 pigs with acute toxicosis 24 to 48 hours after injection were 12.44 ppm in liver, 1.31 ppm in kidney, and 0.32 ppm in skeletal muscle.

• Research Organization: Purdue Univ., West Lafayette, IN
• OSTI ID: 6498006
• Journal Information: J. Am. Vet. Med. Assoc.; (United States), Journal Name: J. Am. Vet. Med. Assoc.; (United States) Vol. 165:6; ISSN JAVMA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
COMPARATIVE EVALUATIONS
DEATH
DOMESTIC ANIMALS
ELEMENTS
INJURIES
MAMMALS
SELENIUM
SEMIMETALS
SWINE
TOXICITY
VERTEBRATES