The response of the granulocytic progenitor cells (CFU-C) of blood and bone marrow in dogs exposed to low doses of x irradiation

Journal Article · Fri Jan 01 04:00:00 EST 1982 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575683· OSTI ID:5794844

Nothdurft, W; Fliedner, T M

The effects of whole-body X irradiation on the granulocytic progenitor cell (CFU-C) population in the peripheral blood of dogs were studied over periods of 65 to 90 days after 22, 44, or 88 R using the in vitro agar culture technique. The number of CFU-C per milliliter blood was significantly reduced within 1 day to 15 to 43% of normal after 44 R and between 1 and 6% of normal after 88 R. After 22 R, there was no significant decrease below the preirradiation values. Regeneration of the number of blood CFU-C commenced between Days 14 and 17. This resulted in somewhat subnormal levels between Days 30 and 35 in the 44-R irradiated dogs. In the 88-R exposed dogs, the extent of regeneration at that time was only 32 to 34% of normal. In this latter group, the CFU-C concentration remained subnormal for more than 65 to 90 days, when it reached 40% of the preirradiation value. The CFU-C concentration in the bone marrow expressed as CFU-C/10/sup 5/ nucleated cells or CFU-C/10/sup 5/ mononuclear cells was below 50% of normal between Days 1 and 15 after 88 R. On Days 21 and 22 the concentration of bone marrow CFU-C increased to between 50 and 100% of the perirradiation levels. However, in all dogs the relative numbers of CFU-C in the bone marrow remained subnormal between Days 30 and 56 after exposure. The results suggest that the circulating hemopoietic stem and/or progenitor cells may serve as a valuable indicator of low-level radiation exposure.

• Research Organization: Univ. of Ulm, Federal Republic of Germany
• OSTI ID: 5794844
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 89:1; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BLOOD FORMATION
BODY
BODY FLUIDS
BONE MARROW
CFU
DOGS
ELECTROMAGNETIC RADIATION
HEMATOPOIETIC SYSTEM
IONIZING RADIATIONS
MAMMALS
MATERIALS
ORGANS
RADIATION EFFECTS
RADIATIONS
TISSUES
VERTEBRATES
X RADIATION