Effects of radiotherapy on the bone marrow granulocytic progenitor cells (CFU/sub c/ of patients with malignant lymphomas. II

Journal Article · Sun Jan 01 04:00:00 EST 1978 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(78)90047-0· OSTI ID:6858613

Morardet, N; Parmentier, C; Hayat, M; Charbord, P

In vitro cultures of granulocytic progenitor cells (CFU/sub c/) were made from both irradiated and non-irradiated bone marrow taken from patients exposed to radiotherapy for hematosarcoma at least 1 year before the culture. Five patients had limited subdiaphragmatic irradiation, and 4 had total lymphoid irradiation. In addition to the cloning rate per 10/sup 5/ nucleated medullary cells which gives the medullary concentration in CFU/sub c/, the cloning rate per 10/sup 5/ metamyelocytes has been established as an index of the effectiveness of the leukopoiesis. The total number of medullary CFU/sub c/ has been calculated and the validity and interest of this calculation are discussed. Medullary granulocytic regeneration in the irradiated zone depends, as for the erythrocytic line, on the medullary volume irradiated. It is practically zero in the irradiated zone in the case of a limited target volume, and significant in the case of total lymphoid irradiation. The number of CFU/sub c/ was found to be normal or subnormal a few years after treatment by mantle field radiotherapy only, but can be reduced when chemotherapy was used after irradiation. It was further reduced after total lymphoid irradiation. A decrease in the CFU/sub c/ compartment can coexist with a normal granulocyte blood count suggesting a compensatory mechanism involving a mitotic amplification between the progenitor cell and the final differentiated cell.

• Research Organization: Inst. Gustave, Roussy
• OSTI ID: 6858613
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 4:9/10; ISSN IOBPD
• Country of Publication: United States
• Language: English

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560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD FORMATION
BODY
BONE MARROW
CHEMOTHERAPY
COBALT 60
COBALT ISOTOPES
DELAYED RADIATION EFFECTS
DISEASES
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
HEMATOPOIETIC SYSTEM
HODGKINS DISEASE
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LEUKOPOIESIS
LYMPHOMAS
MEDICINE
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANS
PATIENTS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SOMATIC CELLS
STEM CELLS
THERAPY
TISSUES
YEARS LIVING RADIOISOTOPES