Effects of radiotherapy on the bone marrow granulocytic progenitor cells (CFU/sub c/) of patients with malignant lymphomas. I

Journal Article · Sun Jan 01 04:00:00 EST 1978 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(78)90046-9· OSTI ID:6858624

Droz, J P; Parmentier, C; Morardet, N; Maraninchi, D; Gardet, P; Tubiana, M

Twenty-three patients with malignant lymphoma (13 cases of Hodgkin's disease and 10 cases of non-Hodgkin's Lymphoma) had their bone marrow studied based on a culture of medullary granulocytic progenitor cells (CFU/sub c/) in methylcellulose. The number of CFU/sub c/ per 10/sup 5/ nucleated medullary cells, which measures the medullary concentration in CFU/sub c/, has been established. These results also have been expressed in terms of the number of CFU/sub c/ per 10/sup 5/ metamyelocytes plated, an index which measures the effectiveness of the leukopoiesis. Additionally, the number of CFU/sub c/ per kg of body weight has been calculated. Before treatment, the number of CFU/sub c/ is significantly lower than in normal subjects. There is a normal or elevated number of circulating granulocytes in these patients which can be explained by means of a mitotic amplification between the progenitor cell and the final differentiated cell. Ten patients were studied immediately after completion of radiotherapy. The number of CFU/sub c/ returned from low to normal for 4 of them, remained low for 3 others, and was reduced from normal to below normal for the last 3. Four patients were studied between 6 and 8 months after radiotherapy. In all 4, the number of CFU/sub c/ returned to normal, whether they had been initially lowered by radiotherapy or not. This normalization resulted from an increase in the concentration of CFU/sub c/ in the non-irradiated zone, and for three of them resulted in part from a medullar regeneration in the irradiated zone.

• Research Organization: Inst. Gustave-Roussy, Villejuif, France
• OSTI ID: 6858624
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 4:9/10; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD FORMATION
BODY
BONE MARROW
DISEASES
EARLY RADIATION EFFECTS
HEMATOPOIETIC SYSTEM
HODGKINS DISEASE
LEUKOPOIESIS
LYMPHOMAS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
RADIATION EFFECTS
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SOMATIC CELLS
STEM CELLS
THERAPY
TISSUES