Hypoxic radioprotection by temporary intestinal ischemia: degradable starch microsphere embolization in the cat

Journal Article · Sun Nov 01 04:00:00 EST 1981 · Am. J. Roentgenol.; (United States)

DOI:https://doi.org/10.2214/ajr.137.5.909· OSTI ID:5793390

Lote, K

Temporary small intestinal ischemia was induced by mesenteric arteriolar embolization of degradable starch microspheres in cats. During ischemia, the small intestine received a surface dose of 7 Gy 200 kV x-ray irradiation. One group of animals also had received 7 Gy to the intact abdomen 72 hr earlier. The risk of thrombosis in small intestinal vessels during or after starch microsphere-induced ischemia combined with irradiation was evaluated by monitoring superior mesenteric arterial blood flow, by determination of blood platelets, fibrinogen, and factor VIII consumed across the mesenteric vascular bed, and by histologic examination of small intestinal vessels. Vascular integrity was inferred from intact response to isoproterenol and vasopressin after the combined trauma of ischemia and irradiation. No signs of thrombosis were detected in small intestinal vessels after temporary ischemia and irradiation. Hypoxic radioprotection of the small intestine in the cat can thus be achieved by mesenteric arterial microembolization of degradable starch spheres without evidence of thrombotic complications or significant vascular damage.

• Research Organization: Univ. of Bergen, Haukeland Sykehus, Norway
• OSTI ID: 5793390
• Journal Information: Am. J. Roentgenol.; (United States), Journal Name: Am. J. Roentgenol.; (United States) Vol. 137:5; ISSN AJROA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BODY
CARBOHYDRATES
CARDIOVASCULAR DISEASES
CATS
DIGESTIVE SYSTEM
DISEASES
DOSES
ELECTROMAGNETIC RADIATION
GASTROINTESTINAL TRACT
INTESTINES
IONIZING RADIATIONS
ISCHEMIA
MAMMALS
MEDICINE
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANS
POLYSACCHARIDES
RADIATION DOSES
RADIATION EFFECTS
RADIATION PROTECTION
RADIATIONS
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
REAGENTS
SACCHARIDES
SIDE EFFECTS
STARCH
THERAPY
THROMBOSIS
VASCULAR DISEASES
VERTEBRATES
X RADIATION