Hypoxic radioprotection by temporary intestinal ischemia: degradable starch microsphere embolization in the cat
Temporary small intestinal ischemia was induced by mesenteric arteriolar embolization of degradable starch microspheres in cats. During ischemia, the small intestine received a surface dose of 7 Gy 200 kV x-ray irradiation. One group of animals also had received 7 Gy to the intact abdomen 72 hr earlier. The risk of thrombosis in small intestinal vessels during or after starch microsphere-induced ischemia combined with irradiation was evaluated by monitoring superior mesenteric arterial blood flow, by determination of blood platelets, fibrinogen, and factor VIII consumed across the mesenteric vascular bed, and by histologic examination of small intestinal vessels. Vascular integrity was inferred from intact response to isoproterenol and vasopressin after the combined trauma of ischemia and irradiation. No signs of thrombosis were detected in small intestinal vessels after temporary ischemia and irradiation. Hypoxic radioprotection of the small intestine in the cat can thus be achieved by mesenteric arterial microembolization of degradable starch spheres without evidence of thrombotic complications or significant vascular damage.
- Research Organization:
- Univ. of Bergen, Haukeland Sykehus, Norway
- OSTI ID:
- 5793390
- Journal Information:
- Am. J. Roentgenol.; (United States), Vol. 137:5
- Country of Publication:
- United States
- Language:
- English
Similar Records
Mesenteric arterial vasopressin in cats: local and systemic effects
Early redistribution of thallium-201 after temporary ischemia
Related Subjects
INTESTINES
ISCHEMIA
RADIATION PROTECTION
RADIOTHERAPY
SIDE EFFECTS
STARCH
RADIOSENSITIVITY EFFECTS
CATS
RADIATION DOSES
RADIATION EFFECTS
THROMBOSIS
X RADIATION
ANIMALS
BODY
CARBOHYDRATES
CARDIOVASCULAR DISEASES
DIGESTIVE SYSTEM
DISEASES
DOSES
ELECTROMAGNETIC RADIATION
GASTROINTESTINAL TRACT
IONIZING RADIATIONS
MAMMALS
MEDICINE
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANS
POLYSACCHARIDES
RADIATIONS
RADIOLOGY
REAGENTS
SACCHARIDES
THERAPY
VASCULAR DISEASES
VERTEBRATES
560152* - Radiation Effects on Animals- Animals