Hypoxic radioprotection by temporary intestinal ischemia: degradable starch microsphere embolization in the cat

Journal Article · Thu Jan 01 04:00:00 EST 1981 · AJR, Am. J. Roentgenol.; (United States)

DOI:https://doi.org/10.2214/ajr.137.5.909· OSTI ID:5576219

Lote, K

Temporary small intestinal ischemia was induced by mesenteric arteriolar embolization of degradable starch microspheres in cats. During ischemia, the small intestine received a surface dose of 7 Gy 200 kV x-ray irradiation. One group of animals also had received 7 Gy to the intact abdomen 72 hr earlier. The risk of thrombosis in small intestinal vessels during or after starch microsphere-induced ischemia combined with irradiation was evaluated by monitoring superior mesenteric arterial blood flow, by determination of blood platelets, fibrinogen, and factor VIII consumed across the mesenteric vascular bed, and by histologic examination of small intestinal vessels. Vascular integrity was inferred from intact response to isoproterenol and vasopressin after the combined trauma of ischemia and irradiation. No signs of thrombosis were detected in small intestinal vessels after temporary ischemia and irradiation. Hypoxic radioprotection of the small intestine in the cat can thus be achieved by mesenteric arterial microembolization of degradable starch spheres without evidence of thrombotic complications of significant vascular damage.

• Research Organization: Surgical Research Laboratory, University of Bergen, Norway
• OSTI ID: 5576219
• Journal Information: AJR, Am. J. Roentgenol.; (United States), Journal Name: AJR, Am. J. Roentgenol.; (United States) Vol. 137:5; ISSN AAJRD
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD FLOW
BLOOD VESSELS
BODY
CARBOHYDRATES
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CATS
DIGESTIVE SYSTEM
DISEASES
ELECTROMAGNETIC RADIATION
EMBOLI
GASTROINTESTINAL TRACT
HISTOLOGY
INTESTINES
IONIZING RADIATIONS
ISCHEMIA
MAMMALS
MICROSPHERES
ORGANIC COMPOUNDS
ORGANS
POLYSACCHARIDES
RADIATION EFFECTS
RADIATION PROTECTION
RADIATIONS
RADIOINDUCTION
REAGENTS
SACCHARIDES
SMALL INTESTINE
STARCH
THROMBOSIS
VASCULAR DISEASES
VERTEBRATES
X RADIATION