Mesenteric arterial vasopressin in cats: local and systemic effects

Journal Article · Fri May 01 04:00:00 EDT 1981 · Am. J. Roentgenol.; (United States)

DOI:https://doi.org/10.2214/ajr.136.5.969· OSTI ID:5456531

Lote, K; Folling, M; Lekven, J; Rosengren, B

The administration of intraaterial mesenteric vasopressin to induce small intestinal ischemia was evaluated in the cat. Small intestinal blood flow was measured by carbonized microsphere distribution and electromagnetic flowmetry. Injection of 99mTc labeled isotope into the superior mesenteric artery was monitored by gamma camera, and isotope kinetics were evaluated as indicators of small intestinal blood flow. Superior mesenteric arterial and small intestinal mucosal blood flow could maximally be reduced to 15%-20% of control by vasopressin administration. 99mTcO4 mesenteric-cardiac transit time was doubled in all animals when small intestinal mucosal blood flow was reduced to less than one-third of control. However, significant blood flow reductions were induced in other abdominal organs, most importantly in retroperitoneal lymph nodes and adipose tissue. Intraarterial mesenteric vasopressin administration does not induce sufficiently severe and specific intestinal ischemia to provide optimal conditions for selective small intestinal hypoxic radioprotection.

• OSTI ID: 5456531
• Journal Information: Am. J. Roentgenol.; (United States), Journal Name: Am. J. Roentgenol.; (United States) Vol. 136:5; ISSN AJROA
• Country of Publication: United States
• Language: English

Related Subjects

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL HALF-LIFE
BLOOD FLOW
BODY
CAMERAS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CATS
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DIGESTIVE SYSTEM
DISEASES
GAMMA CAMERAS
GASTROINTESTINAL TRACT
HEART
HORMONES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
INTESTINES
ISCHEMIA
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MEASURING METHODS
MICROSPHERES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PEPTIDE HORMONES
PITUITARY HORMONES
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
SCINTISCANNING
SMALL INTESTINE
TECHNETIUM 99
TECHNETIUM ISOTOPES
USES
VASCULAR DISEASES
VASOPRESSIN
VELOCITY
VERTEBRATES
YEARS LIVING RADIOISOTOPES