Absence of generalized immunosuppression in C57B1/6 mice during progressive growth of syngeneic T-lymphoma EL-4 and of Lewis 3LL lung carcinoma

Journal Article · Sat Nov 01 04:00:00 EST 1986 · Bull. Exp. Biol. Med. (Engl. Transl.); (United States)

DOI:https://doi.org/10.1007/BF00839614· OSTI ID:5779688

Fuks, B B; Malaitsev, I M; Bogdanova, I M

The authors describe the proliferative response of lymphocytes to mitogens and the generation of allospecific CTL in vivo were investigated in C57BL/6 mice during progressive growth of syngeneic T lymphoma EL-4 and Lewis carcinoma 3LL. Interleuken 2 activity was estimated from the incorporation of /sup 3/H-thymidine into 4-day T blast cells. Radioactivity of the samples was determined on a Packard-Tricarb scintillation beta-counter, after sedimentation on filters of the material precipitated by TCA. Spleen cells of immunized mice were used as the source of CTL in the 4-hourly test of /sup 51/Cr release from target cells. It is concluded that the level of Interleuken 2 production in mice with tumors EL-4 and 3LL was high enough to generate an effective CTL response and that the absence of CTL response to a syngeneic tumor cannot be explained by a nonspecific suppressor effect of the tumor carrier state on the immune system.

• Research Organization: Research Institute of Human Morphology, Moscow, USSR
• OSTI ID: 5779688
• Journal Information: Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Journal Name: Bull. Exp. Biol. Med. (Engl. Transl.); (United States) Vol. 101:6; ISSN BEXBA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
AGGLUTININS
ANIMAL CELLS
ANIMALS
ANTIBODIES
ANTIMITOTIC DRUGS
AZINES
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOSYNTHESIS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARCINOMAS
CELL CULTURES
CELL PROLIFERATION
CHROMIUM 51
CHROMIUM ISOTOPES
CONCANAVALIN
CONNECTIVE TISSUE CELLS
COUNTING TECHNIQUES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GROWTH
HEMAGGLUTININS
HETEROCYCLIC COMPOUNDS
IMMUNE REACTIONS
IMMUNOASSAY
IMMUNOLOGY
IMMUNOSUPPRESSION
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LABELLING
LECTINS
LEUKOCYTES
LYMPHOCYTES
LYMPHOMAS
MAMMALS
MATERIALS
MICE
MITOGENS
NEOPLASMS
NUCLEI
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRIMIDINES
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNOLOGY
RADIOISOTOPES
RIBOSIDES
RODENTS
SCINTILLATION COUNTING
SOMATIC CELLS
SPLEEN CELLS
SYNTHESIS
THYMIDINE
TRACER TECHNIQUES
TRITIUM COMPOUNDS
TUMOR CELLS
VERTEBRATES