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Evaluation of energy spectral information in nuclear imaging and investigation of protein binding of radiogallium. Progress report, October 1, 1980-November 30, 1983

Technical Report ·
OSTI ID:5764782
The gamma camera-computer interface was modified to allow the computer to accept both a spatial and energy address from each incoming photon. We have used this system to study the effect of scatter on measurement of ventricular function by ejection fraction (EF). Our preliminary results indicate that energy windowing, which decreases scatter fraction, increases recorded ejection fraction, EF. These results indicate that energy resolution and windowing must be considered when normal EF values are established, patients are studied on different instruments, or old equipment is replaced with newer model cameras. We have also further elucidated possible mechanisms by which Gallium-67 localizes in inflammatory lesions and tumors. Gallium-67 can transfer from transferrin and lactoferrin to ferritin. Transfer can be influenced by a number of mediators. We have studied the localization of Gallium-67 in a benign non-infected bone lesion (fracture). Although Gallium-67 uptake in such lesions appears on imaging to be less than /sup 99m/Tc-MDP uptake, the actual quantitative uptake in bone is identical. We are currently conducting studies of Gallium-67 uptake in an osteomyelitis model in rabbits in order to determine if such uptake accurately reflects the effect of antibiotic treatment.
Research Organization:
Yale Univ., New Haven, CT (USA)
DOE Contract Number:
AC02-78EV04625
OSTI ID:
5764782
Report Number(s):
DOE/EV/04625-T3; ON: DE83014765
Country of Publication:
United States
Language:
English

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Evaluation of energy spectral information in nuclear imaging and investigation of protein binding of radiogallium. Progress report, October 1, 1981-November 30, 1982. [ODIFICATIONS; COMPUTERS; EQUIPMENT INTERFACES; OPTIMIZATION; LACTOFERRIN; TRANSFERRIN; BACTERIA; PATHOGENS; GALLIUM 67; RABBITS; UPTAKE; MODIFICATIONS; SPATIAL RESOLUTION]
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Evaluation of energy spectral information in nuclear imaging and investigation of protein binding of radiogallium. Progress report, October 1, 1980-September 30, 1981
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Role of iron-binding proteins and enhanced capillary permeability on the accumulation of gallium-67
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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
560172 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BODY
CAMERAS
CARDIOVASCULAR SYSTEM
DAYS LIVING RADIOISOTOPES
DISEASES
DYNAMIC FUNCTION STUDIES
ELECTRON CAPTURE RADIOISOTOPES
GALLIUM 67
GALLIUM ISOTOPES
GAMMA CAMERAS
HEART
IMAGE PROCESSING
INFLAMMATION
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OSTEOMYELITIS
PATHOLOGICAL CHANGES
PROCESSING
RABBITS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RESEARCH PROGRAMS
SKELETAL DISEASES
SKELETON
SYMPTOMS
UPTAKE
VERTEBRATES