Evaluation of energy spectral information in nuclear imaging and investigation of protein binding of radiogallium. Progress report, October 1, 1980-September 30, 1981

Technical Report · Thu Sep 10 04:00:00 EDT 1981

OSTI ID:5176892

Hoffer, P B

Most of the planned modifications on the gamma camera-computer interface are completed. These modifications will allow to determine the contribution of scatter radiation to inaccuracies in cardiac volume and ejection fraction determinations and allow for correction of these inaccuracies. The modifications will also allow testing of the weighted window imaging concept. Specific accomplishments include construction of an energy interface between ZLC-75 camera and DEC gamma 11/34 computer and development and testing of new programs to allow region of interest energy analysis and determination of photopeak and scatter contributions. A new type of converging collimator was built and is being tested which corrects for tissue attenuation at the average cardiac ventricular depth and may prove useful in cardiac chamber volume estimates. A new generator system using a /sup 195m/Hg parent to produce a /sup 195m/Au daughter which will be useful for cardiac studies is being evaluated. The mechanisms by which Ga-67 localizes in abscess and tumor were further elucidated by demonstrating that Ga-67 can transfer from transferrin to ferritin directly. This transfer is facilitated by certain mediators, especially the organic phosphates and does not appear to be energy dependent. A method of labelling viable bacteria with /sup 111/In oxine was developed, and the exact role of siderophores in Ga-67 uptake in bacteria and also Ga-67 uptake in monocytes are being investigated. (ERB)

• Research Organization: Yale Univ., New Haven, CT (USA)
• DOE Contract Number: AS02-78EV04625
• OSTI ID: 5176892
• Report Number(s): DOE/EV/04625-2; ON: DE82002111
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702 -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
400703 -- Radiochemistry & Nuclear Chemistry-- Radioisotope Production
440300 -- Miscellaneous Instruments-- (-1989)
47 OTHER INSTRUMENTATION
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
560171 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Man-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSCESSES
AZINES
BACTERIA
BETA DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CAMERAS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CHEMISTRY
COMPLEXES
COMPUTERS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DEC COMPUTERS
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EQUIPMENT INTERFACES
ERRORS
EVEN-ODD NUCLEI
GALLIUM 67
GALLIUM ISOTOPES
GAMMA CAMERAS
GLOBULINS
GLOBULINS-BETA
GOLD 195
GOLD ISOTOPES
HEART
HEAVY NUCLEI
HETEROCYCLIC COMPOUNDS
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IRON COMPLEXES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE PRODUCTION
ISOTOPES
LABELLING
LEUKOCYTES
MATERIALS
MERCURY ISOTOPES
METALLOPROTEINS
MICROORGANISMS
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PROTEINS
PYRIDINES
QUINOLINES
RADIOCHEMISTRY
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
TRANSITION ELEMENT COMPLEXES
UPTAKE
USES