Evaluation of energy spectral information in nuclear imaging and investigation of protein binding of radiogallium. Progress report, October 1, 1981-November 30, 1982. [ODIFICATIONS; COMPUTERS; EQUIPMENT INTERFACES; OPTIMIZATION; LACTOFERRIN; TRANSFERRIN; BACTERIA; PATHOGENS; GALLIUM 67; RABBITS; UPTAKE; MODIFICATIONS; SPATIAL RESOLUTION]
All of the planned modifications on the gamma camera-computer interface are completed. Currently in process is the collecting and analyzing of data from clinical studies to determine the contribution of scatter radiation to inaccuracies in cardiac volume and ejection fraction determinations. Specific accomplishments include addition of PASCAL as a programming language which allows more flexible interfacing with other computer systems for graphics and data analysis. The program has also been modified to allow testing of the weighted window imaging concept. The mechanisms of Ga-67 localization were further elucidated by studying the role of various mediators on the transfer of Ga-67 from lactoferrin to transferrin. The role of siderophores in the uptake of Ga-67 by pathogenic bacteria was studied and it was discovered that much of the Ga-67 which is taken up is not extractable in solvents customarily used for siderophore isolation. This suggests that either pathogenic bacteria utilize non-hydroxamate type siderophores, or perhaps, some other mechanism in incorporating Ga-67. A rabbit osteomyelitis model was developed to study Ga-67 uptake in this lesion. As ancillary projects, the effect of improved intrinsic camera resolution on lesion detection was studied and a colorimetric method of identifying radiopharmaceuticals was developed.
- Research Organization:
- Yale Univ., New Haven, CT (USA). Dept. of Diagnostic Radiology
- DOE Contract Number:
- AC02-78EV04625
- OSTI ID:
- 5176877
- Report Number(s):
- DOE/EV/04625-T2; ON: DE82019144
- Country of Publication:
- United States
- Language:
- English
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ABSORPTION SPECTROSCOPY
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BIOLOGICAL MODELS
CAMERAS
CARBOHYDRATES
COMPUTER GRAPHICS
COMPUTERS
DATA ANALYSIS
DAYS LIVING RADIOISOTOPES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EQUIPMENT INTERFACES
GALLIUM 67
GALLIUM ISOTOPES
GAMMA CAMERAS
GLOBULINS
GLOBULINS-BETA
GLUCOPROTEINS
INTERMEDIATE MASS NUCLEI
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
METALLOPROTEINS
MICROORGANISMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
OSTEOMYELITIS
PERFORMANCE
PROGRAMMING LANGUAGES
PROTEINS
RADIOISOTOPES
RADIOPHARMACEUTICALS
RESOLUTION
SACCHARIDES
SKELETAL DISEASES
SPECTROSCOPY
UPTAKE
VERTEBRATES