Role of iron-binding proteins and enhanced capillary permeability on the accumulation of gallium-67
We studied the role of the iron-binding proteins transferrin and lactoferrin and of increased capillary permeability on the accumulation of gallium-67 in rabbits. Intramuscular injection of histamine caused accumulation of gallium-67 (injected iv as citrate), and of Tc-99m DTPA, at the im injection site. Normal saline and albumin did not. Intramuscular injection of transferrin or lactoferrin similarly caused Ga-67 uptake. No accumulation of Tc-99m DTPA was observed at the site of transferrin injection but there was a slight accumulation at the site of lactoferrin injection. Prior saturation of transferrin or lactoferrin with ferric ion abolished their effect on Ga-67 accmulation. Gallium-67, pre-bound to transferrin in vitro, did not accumulate at the site of histamine or transferrin injection, but there was a slight accumulation at the lactoferrin site. Our results suggest that either increased capillary permeability of iron-binding proteins can cause local uptake of Ga-67. Since these factors are present at sites of inflammation, they may contribute to the accumulation of gallium in inflammatory lesions.
- Research Organization:
- Johns Hopkins Medical Institions, Baltimore, MD
- OSTI ID:
- 5340234
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 21:1; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
AZOLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL LOCALIZATION
BLOOD VESSELS
BODY
CAPILLARIES
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
GALLIUM 67
GALLIUM ISOTOPES
GLOBULINS
GLOBULINS-BETA
HETEROCYCLIC COMPOUNDS
HISTAMINE
HOURS LIVING RADIOISOTOPES
IMIDAZOLES
INFLAMMATION
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PERMEABILITY
PROTEINS
RABBITS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RESPONSE MODIFYING FACTORS
SCINTISCANNING
TECHNETIUM 99
TECHNETIUM ISOTOPES
TRANSFERRIN
VERTEBRATES
YEARS LIVING RADIOISOTOPES