Mechanism of gallium-67 accumulation in tumors
Neoplasms are characterized by increased perfusion, increased permeability of their capillary beds to macromolecules, and a delay in new lymphatic vessel growth. These lead to the increased entry and residency time of macromolecules in the interstitial space of tumors. Multiple factors contribute to the localization of /sup 67/Ga in tumors. Adequate blood supply is essential; at areas with no blood supply such as the necrotic center of a large tumor, there is no /sup 67/Ga accumulation. Gallium-67, mainly in the form of transferrin-67Ga complex, is delivered to the tumor through capillaries with increased permeability. In tumors, some /sup 67/Ga is taken up by tumor cells; some may also be taken up by inflammatory cells when they are present. Gallium-67 binding proteins, such as lactoferrin or ferritin, may also contribute to the accumulation and retention of /sup 67/Ga in tumors; however, their roles are less clear. The intensity of these various factors determine their relative contribution and the degree of /sup 67/Ga accumulation in tumors.56 references.
- OSTI ID:
- 5019943
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 7; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560171 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Man-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
CARBOHYDRATES
COMPLEXES
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
FERRITIN
GALLIUM 67
GALLIUM ISOTOPES
GLOBULINS
GLUCOPROTEINS
IMAGES
IN VITRO
INTERMEDIATE MASS NUCLEI
IRON COMPLEXES
ISOTOPES
LACTOFERRIN
MAMMALS
METALLOPROTEINS
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PROTEINS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RATS
RODENTS
SACCHARIDES
TRANSITION ELEMENT COMPLEXES
UPTAKE
VERTEBRATES