Radioimmunoguided surgery using iodine 125 B72. 3 in patients with colorectal cancer

Journal Article · Fri Mar 01 00:00:00 EST 1991 · Archives of Surgery (Chicago); (USA)

DOI:https://doi.org/10.1001/archsurg.1991.01410270095015· OSTI ID:5760605

Cohen, A M; Martin, Jr, E W; Lavery, I; Daly, J; Sardi, A; Aitken, D; Bland, K; Mojzisik, C; Hinkle, G ^[1]

---

1. Memorial Sloan-Kettering Cancer Center, New York, NY (USA)

Preliminary data using B72.3 murine monoclonal antibody labeled with iodine 125 suggested that both clinically apparent as well as occult sites of colorectal cancer could be identified intraoperatively using a hand-held gamma detecting probe. We report the preliminary data of a multicenter trial of this approach in patients with primary or recurrent colorectal cancer. One hundred four patients with primary, suspected, or known recurrent colorectal cancer received an intravenous infusion of 1 mg of B72.3 monoclonal antibody radiolabeled with 7.4 x 10 Bq of iodine 125. Twenty-six patients with primary colorectal cancer and 72 patients with recurrent colorectal cancer were examined. Using the gamma detecting probe, 78% of the patients had localization of the antibody in their tumor; this included 75% of primary tumor sites and 63% of all recurrent tumor sites; 9.2% of all tumor sites identified represented occult sites detected only with the gamma detecting probe. The overall sensitivity was 77% and a predictive value of a positive detection was 78%. A total of 30 occult sites in 26 patients were identified. In patients with recurrent cancer, the antibody study provided unique data that precluded resection in 10 patients, and in another eight patients it extended the potentially curative procedure.

• OSTI ID: 5760605
• Journal Information: Archives of Surgery (Chicago); (USA), Vol. 126:3; ISSN 0004-0010
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
LARGE INTESTINE
NEOPLASMS
RADIOIMMUNOTHERAPY
SENSITIVITY ANALYSIS
RECTUM
IODINE 125
MONOCLONAL ANTIBODIES
PATIENTS
ANTIBODIES
BETA DECAY RADIOISOTOPES
BODY
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
GASTROINTESTINAL TRACT
IMMUNOLOGY
IMMUNOTHERAPY
INTERMEDIATE MASS NUCLEI
INTESTINES
IODINE ISOTOPES
ISOTOPES
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOIMMUNOLOGY
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
THERAPY
550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-)