Radioimmunoguided surgery using the monoclonal antibody B72. 3 in colorectal tumors

Journal Article · Thu Oct 01 04:00:00 EDT 1987 · Dis. Colon Rectum; (United States)

DOI:https://doi.org/10.1007/BF02554623· OSTI ID:5726051

Sickle-Santanello, B J; O'Dwyer, P J; Mojzisik, C; Tuttle, S E; Hinkle, G H; Rousseau, M; Schlom, J; Colcher, D; Thurston, M O; Nieroda, C

The authors have developed a hand-held gamma-detecting probe (GDP) for intraoperative use that improves the sensitivity of external radioimmunodetection. Radiolabeled monoclonal antibody (MAb) B72.3 was injected in six patients with primary colorectal cancer and 31 patients with recurrent colorectal cancer an average of 16 days preoperatively. The GDP localized the MAb B72.3 in 83 percent of sites. The technique, known as a radioimmunoguided surgery (RIGS) system did not alter the surgical procedure in patients with primary colorectal cancer but did alter the approach in 26 percent (8/31) of patients with recurrent colorectal cancer. Two patients avoided unnecessary liver resections and two underwent extraabdominal approaches to document their disease. The RIGS system may influence the short-term morbidity and mortality of surgery for colorectal cancer. Larger series and longer follow-up are needed to determine whether the RIGS system confers a survival advantage to the patient with colorectal cancer.

• Research Organization: Ohio State Univ., Columbus
• OSTI ID: 5726051
• Journal Information: Dis. Colon Rectum; (United States), Journal Name: Dis. Colon Rectum; (United States) Vol. 30:10; ISSN DICRA
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
ANTIBODIES
BIOLOGICAL LOCALIZATION
BODY
DIGESTIVE SYSTEM
DISEASES
GASTROINTESTINAL TRACT
IMMUNOASSAY
IMMUNOLOGY
INTESTINES
ISOTOPE APPLICATIONS
LABELLING
LARGE INTESTINE
MEDICINE
MONOCLONAL ANTIBODIES
NEOPLASMS
ORGANS
PATIENTS
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNOLOGY
RECTUM
SURGERY
TRACER TECHNIQUES