Radioimmunoguided surgery in primary colon cancer

Journal Article · Mon Jan 01 04:00:00 EST 1990 · Cancer Detection and Prevention; (USA)

OSTI ID:5985230

Nieroda, C A; Mojzisik, C; Sardi, A; Ferrara, P J; Hinkle, G; Thurston, M O; Martin, Jr, E W ^[1]

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1. National Institutes of Health, Bethesda, MD (USA)

Radioimmunoguided surgery (RIGS), the intraoperative use of a hand-held gamma detecting probe (GDP) to identify tissue containing radiolabeled monoclonal antibody (MAb), was performed upon 30 patients with primary colon carcinoma. Each patient received an intravenous injection of MAb B72.3 (1.0 to 0.25 mg) radiolabeled with {sup 125}I (5.0 to 1.0 mCi) 8 to 34 days before exploration. The GDP was used to measure radioactivity in colon tissue, tumor bed, nodal drainage areas, and areas of suspected metastases. Antibody localized to histologically documented tumor in 23 of 30 patients (77%). Tumor margins were more clearly defined in 20 of 30 patients (67%). GDP counts led to major alterations in surgical resection in five patients (17%) and changes in adjuvant therapy in four (14%). GDP counts identified occult liver metastases in two patients (7%) and correctly indicated the benign nature of liver masses in three (10%). In four patients (13%), occult nodal metastases were identified. RIGS can precisely delineate tumor margins, define the extent of nodal involvement, and localize occult tumor, providing a method of immediate intraoperative staging that may lessen recurrences and produce higher survival rates.

• OSTI ID: 5985230
• Journal Information: Cancer Detection and Prevention; (USA), Journal Name: Cancer Detection and Prevention; (USA) Vol. 14:6; ISSN 0361-090X; ISSN CDPRD
• Country of Publication: United States
• Language: English

Related Subjects

550604* -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANTIBODIES
BODY
CARCINOMAS
DIGESTIVE SYSTEM
DISEASES
GASTROINTESTINAL TRACT
IMMUNOLOGY
IMMUNOTHERAPY
INTESTINES
LARGE INTESTINE
MEDICINE
METASTASES
MONOCLONAL ANTIBODIES
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
RADIOIMMUNOLOGY
RADIOIMMUNOTHERAPY
RADIOLOGY
RADIOTHERAPY
SURVIVAL CURVES
THERAPY