Radioimmunoguided surgery using monoclonal antibody

Journal Article · Tue Nov 01 04:00:00 EST 1988 · Am. J. Surg.; (United States)

DOI:https://doi.org/10.1016/S0002-9610(88)80193-4· OSTI ID:6581972

Martin, Jr, E W; Mojzisik, C M; Hinkle, Jr, G H; Sampsel, J; Siddiqi, M A; Tuttle, S E; Sickle-Santanello, B; Colcher, D; Thurston, M O; Bell, J G

The potential proficiency of radioimmunoguided surgery in the intraoperative detection of tumors was assessed using labeled monoclonal antibody B72.3 in 66 patients with tissue-proved tumor. Monoclonal antibody B72.3 was injected 5 to 42 days preoperatively, and the hand-held gamma-detecting probe was used intraoperatively to detect the presence of tumor. Intraoperative probe counts of less than 20 every 2 seconds, or tumor-to-adjacent normal tissue ratios less than 2:1 were considered negative (system failure). Positive probe counts were detected in 5 of 6 patients with primary colon cancer (83 percent), in 31 of 39 patients with recurrent colon cancer (79 percent), in 4 of 5 patients with gastric cancer (80 percent), in 3 of 8 patients with breast cancer (37.5 percent), and in 4 of 8 patients with ovarian cancer (50 percent) undergoing second-look procedures. Additional patients in each group were scored as borderline positive. Overall, radioimmunoguided surgery using B72.3 identified tumors in 47 patients (71.2 percent), bordered on positive in 6 patients (9.1 percent), and failed to identify tumor in 13 patients (19.7 percent). Improved selection of patients for antigen-positive tumors, the use of higher affinity second-generation antibodies, alternate routes of antibody administration, alternate radionuclides, and more sophisticatedly bioengineered antibodies and antibody combinations should all lead to improvements in radioimmunoguided surgery.

• Research Organization: Ohio State Univ. College of Medicine, Columbus (USA)
• OSTI ID: 6581972
• Journal Information: Am. J. Surg.; (United States), Journal Name: Am. J. Surg.; (United States) Vol. 156:5; ISSN AJSUA
• Country of Publication: United States
• Language: English

Related Subjects

550600 -- Medicine
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANTIBODIES
BODY
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC USES
DIGESTIVE SYSTEM
DISEASES
FEMALE GENITALS
GASTROINTESTINAL TRACT
GLANDS
GONADS
IMMUNOASSAY
IMMUNOLOGY
INTESTINES
ISOTOPE APPLICATIONS
LARGE INTESTINE
MAMMARY GLANDS
MEDICINE
MONOCLONAL ANTIBODIES
NEOPLASMS
ORGANS
OVARIES
PATIENTS
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNOLOGY
SCINTILLATION COUNTING
SURGERY
TRACER TECHNIQUES
USES