Inhibition of hybrid resistance to lymphomas by inactivated tumor cells in lethally irradiated mice
Journal Article
·
· Transplantation; (United States)
Two murine lymphomas, L5MF-22 of B10.129(5M) (H-2/sup b/) origin and P388 of DBA/2 (H-2/sup d/) origin, were inoculated into lethally irradiated hybrid (C57BL/6 x DBA/2)F/sub 1/ (B6D2F/sub 1/) mice (H-2/sup b//H-2/sup d/). Marked localized graft resistance was found in the spleen and occasionally in the liver of recipient mice as a result of a non-T-dependent hybrid resistance (HR). Significant reduction of HR of B6D2F/sub 1/ mice could be obtained when viable lymphoma cells were inoculated along with inactivated cells of the same tumor or of genetically related leukemias. These results suggest that in vivo competition for HR effectors can take place in mouse spleen and liver leading to a depression of the localized resistance.
- Research Organization:
- Univ. of Perugia, Perugia, Italy
- OSTI ID:
- 5732746
- Journal Information:
- Transplantation; (United States), Journal Name: Transplantation; (United States) Vol. 32:5; ISSN TRPLA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550900 -- Pathology
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BODY
CELL PROLIFERATION
CHIMERAS
CONTROL
DATA
DIGESTIVE SYSTEM
DISEASES
EXPERIMENTAL DATA
GENETIC CONTROL
GLANDS
HEMIC DISEASES
IMMUNE REACTIONS
INACTIVATION
INFORMATION
INHIBITION
LEUKEMIA
LIVER
LYMPHOMAS
MAMMALS
MICE
MOSAICISM
NEOPLASMS
NUMERICAL DATA
ORGANS
PEST CONTROL
RADIATION CHIMERAS
RODENTS
SPLEEN
TUMOR CELLS
VERTEBRATES
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BODY
CELL PROLIFERATION
CHIMERAS
CONTROL
DATA
DIGESTIVE SYSTEM
DISEASES
EXPERIMENTAL DATA
GENETIC CONTROL
GLANDS
HEMIC DISEASES
IMMUNE REACTIONS
INACTIVATION
INFORMATION
INHIBITION
LEUKEMIA
LIVER
LYMPHOMAS
MAMMALS
MICE
MOSAICISM
NEOPLASMS
NUMERICAL DATA
ORGANS
PEST CONTROL
RADIATION CHIMERAS
RODENTS
SPLEEN
TUMOR CELLS
VERTEBRATES