Mouse Peyer's patches contain T cells capable of inducing the graft-versus-host reaction (GVHR). [Gamma radiation]
Journal Article
·
· Transplantation; (United States)
OSTI ID:6585638
The potential of cells from the Peyer's patches (PP) of normal adult DBA/2 Tru mice (DBA/2) to induce a graft-versus-host reaction when injected into (C57BL/6 Tru x DBA/2 Tru)F/sub 1/ hybrid (B6D2F/sub 1/) mice was studied. The injection of 10/sup 6/ to 10/sup 7/ DBA/2 PP or spleen cells i.p. into neonatal F/sub 1/ mice produced a striking splenomegaly. Comparable doses of parental PP or spleen cells injected into a rear footpad of adult F/sub 1/ mice also induced a marked enlargement of the draining popliteal lymph node. In addition, PP cells were also capable of producing a lethal runting syndrome when injected i.v. into sublethally irradiated adult F/sub 1/ recipients. In all assays, injection of syngeneic B6D2F/sub 1/ cells had little or no effect. Treatment of the DBA/2 PP cells with anti-theta serum and complement abolished their capacity to induce splenomegaly in neonatal F/sub 1/ mice. The graft-versus-host reaction activity of the PP cells could also be eliminated by thymus deprivation of the donor DBA/2 mice. These data are contradictory to previous findings in which it was observed that mouse PP cells were unable to induce graft-versus-host reaction.
- Research Organization:
- Trudeau Inst., Inc., Saranac Lake, NY
- OSTI ID:
- 6585638
- Journal Information:
- Transplantation; (United States), Journal Name: Transplantation; (United States) Vol. 26:3; ISSN TRPLA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DISEASES
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
GRAFT-HOST REACTION
IONIZING RADIATIONS
LYMPHATIC SYSTEM
MAMMALS
MICE
NEONATES
ORGANS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIATIONS
RODENTS
SOMATIC CELLS
SPLEEN CELLS
SPLENOMEGALY
SYMPTOMS
THYMOCYTES
THYMUS
TRANSPLANTS
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DISEASES
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
GRAFT-HOST REACTION
IONIZING RADIATIONS
LYMPHATIC SYSTEM
MAMMALS
MICE
NEONATES
ORGANS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIATIONS
RODENTS
SOMATIC CELLS
SPLEEN CELLS
SPLENOMEGALY
SYMPTOMS
THYMOCYTES
THYMUS
TRANSPLANTS
VERTEBRATES