Mouse brain: an immunologically privileged site for natural resistance against lymphoma cells

Journal Article · Mon Feb 01 04:00:00 EST 1982 · J. Immunol.; (United States)

OSTI ID:5672866

Circolo, A; Bianchi, R; Nardelli, B; Rivosecchi-Merletti, P; Bonmassar, E

The present study deals with classical graft response and natural resistance against lymphoma cells in mouse brain, evaluated in terms of either survival times or extent of lymphoma cell proliferation measured by the percentage of /sup 125/lUdR uptake. The results show the following: a) CGR was easily detected in the brain of allogeneic nonirradiated recipients by using either parameter. CGR was easily abrogated by total-body irradiation and was absent in ''nude'' recipients when tested by the /sup 125/lUdR uptake technique. b) No difference in the growth patterns of H-2/sup b/ lymphoma cells was detected in the brain of irradiated histocompatible or Hh-incompatible hybrid (H-2/sup b/ / H-2/sup d/) or allogeneic (H-2/sup b/, H-2/sup i//sup 5/) mice or Hh-compatible H-2/sup h//sup 2/ hosts inoculated intracerebrally (i.c.) with the tumor. On the contrary, strong resistance to lymphoma graft was confirmed in the spleen of irradiated Hh-incompatible recipients inoculated i.v. with the tumor. c) No impairment of splenic resistance against lymphoma cells was afforded by the simultaneous administration of the same tumor into the brain, thus ruling out the possibility that the i.c. challenge with lymphoma cells abrogated NR of the host. d) Mortality studies in nonirradiated Hh-incompatible hybrid or nude mice suggested that only marginal NR could be detected in mouse brain. These data suggest that mouse brain can be considered an ''immunologically privileged'' site for NR more than for CGR, and provide the immunologic bases for explaining the successful take of xenogeneic lymphoid tumors in the brain of nude mice.

• Research Organization: Univ. of Perugia, IT
• OSTI ID: 5672866
• Journal Information: J. Immunol.; (United States), Journal Name: J. Immunol.; (United States) Vol. 128:2; ISSN JOIMA
• Country of Publication: United States
• Language: English

Related Subjects

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560152 -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIMETABOLITES
AZINES
BETA DECAY RADIOISOTOPES
BODY
BRAIN
CELL PROLIFERATION
CENTRAL NERVOUS SYSTEM
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EXTERNAL IRRADIATION
GLANDS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IMMUNOSUPPRESSION
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
IODODEOXYURIDINE
IODOURACILS
IRRADIATION
ISOTOPE APPLICATIONS
ISOTOPES
LIVER
LUNGS
LYMPHOMAS
MAMMALS
MICE
NEOPLASMS
NERVOUS SYSTEM
NUCLEI
NUCLEOSIDES
NUCLEOTIDES
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRIMIDINES
RADIOINDUCTION
RADIOISOTOPES
RADIOSENSITIVITY
RESPIRATORY SYSTEM
RIBOSIDES
RODENTS
SPLEEN
TRACER TECHNIQUES
URACILS
VERTEBRATES
WHOLE-BODY IRRADIATION