Impaired growth of a radiation-induced lymphoma in intact or lethally irradiated allogeneic athymic (nude) mice
Journal Article
·
· Transplantation (Baltimore)
Radioinduced lymphomas were maintained in mice by serial transplantation of neoplastic cells and mortality of mice was recorded for 60 days. Mice were x- irradiated at a dose rate of 137 R/min. Lethally irradiated mice were resistant to an incompatible lymphoma as determined by 125I-IUdR uptake values of the spleen. The lack of influence of an immunodepressive factor and the observation that lethal irradiation did not abrogate the relative resistance to tumor challenge appeared to exclude the possibility that the reduced growth of the lymphoma in nude mice is the result of a conventional allograft reaction.
- Research Organization:
- National Cancer Inst., Bethesda, MD
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-33-005796
- OSTI ID:
- 4168874
- Journal Information:
- Transplantation (Baltimore), Journal Name: Transplantation (Baltimore) Journal Issue: 4 Vol. 20; ISSN 0041-1337
- Country of Publication:
- United States
- Language:
- English
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