Effects of recombination-deficient and repair-deficient loci on meiotic and mitotic chromosome behavior in Drosophila melanogaster

Journal Article · Tue Jan 01 04:00:00 EST 1980 · Basic Life Sci.; (United States)

DOI:https://doi.org/10.1007/978-1-4684-3842-0_13· OSTI ID:5714963

Baker, B S; Gatti, M; Carpenter, A T; Pimpinelli, S; Smith, D A

The results of recent genetic and cytological studies on recombination-defective and repair-defective mutants of Drosophila melanogaster are summarized. These studies show that there is substantial overlap between the functions used in various aspects of DNA metabolism in Drosophila. Most loci first identified by either recombination-defective or mutagen-sensitive mutants have been shown also to function in nonmutagenized mitotic cells where their action is necessary to maintain the integrity of the genome: mutants at particular loci produce elevated frequencies of chromosome breakage, mitotic exchange, mutation, and/or chromosome loss. Genetic studies of meiotic recombination show that many of the loci identified by recombination-defective mutants restrict where along the chromosome arms exchange may occur. Recent EM studies suggest that the products of at least some of these loci are components of recombination nodules. Region-specific control of DNA metabolism is also indicated by the finding of nonrandom patterns of chromosome breakage in some mutagen-sensitive mutants. Recombination-defective mutants at two loci have been studied for their effects on sister chromatid exchanges and x-ray induced aberrations. Mutants at both loci are defective in steps necessary for the production of symmetrical chromatid interchanges but have little effect on SCEs.

• OSTI ID: 5714963
• Journal Information: Basic Life Sci.; (United States), Journal Name: Basic Life Sci.; (United States) Vol. 15; ISSN BLFSB
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
560114 -- Radiation Effects on Biochemicals-- In Animals-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ARTHROPODS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CELL DIVISION
CHROMOSOMAL ABERRATIONS
DIPTERA
DNA
DROSOPHILA
ELECTROMAGNETIC RADIATION
FLIES
FRUIT FLIES
GENES
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
INSECTS
INVERTEBRATES
IONIZING RADIATIONS
MEIOSIS
METABOLISM
MITOSIS
MUTATION FREQUENCY
MUTATIONS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RECOVERY
REPAIR
SISTER CHROMATID EXCHANGES
X RADIATION