Third-chromosome mutagen-sensitive mutants of Drosophila melanogaster
Journal Article
·
· Genetics; (United States)
OSTI ID:6315612
A total of 34 third chromosomes of Drosophila melanogaster that render homozygous larvae hypersensitive to killing by chemical mutagens have been isolated. Genetic analyses have placed responsible mutations in more than eleven complementation groups. Mutants in three complementation groups are strongly sensitive to methyl methanesulfonate, those in one are sensitive to nitrogen mustard, and mutants in six groups are hypersensitive to both mutagens. Eight of the ten loci mapped fall within 15% of the genetic map that encompasses the centromere of chromosome 3. Mutants from four of the complementation groups are associated with moderate to strong meiotic effects in females. Preliminary biochemical analyses have implicated seven of these loci in DNA metabolism.
- Research Organization:
- Univ. of California, Davis
- OSTI ID:
- 6315612
- Journal Information:
- Genetics; (United States), Journal Name: Genetics; (United States) Vol. 97:3-4; ISSN GENTA
- Country of Publication:
- United States
- Language:
- English
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·
OSTI ID:7323913
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Related Subjects
550400* -- Genetics
550700 -- Microbiology
59 BASIC BIOLOGICAL SCIENCES
ALKYLATING AGENTS
AMINES
ANIMALS
ARTHROPODS
BIOLOGICAL EFFECTS
CELL DIVISION
CELL KILLING
CHROMOSOMES
DIPTERA
DNA
DROSOPHILA
ESTERS
FLIES
FRUIT FLIES
GENETIC EFFECTS
GENETIC MAPPING
INSECTS
INVERTEBRATES
LARVAE
MAPPING
MEIOSIS
METHYL METHANESULFONATE
MUTAGENS
MUTANTS
NITROGEN MUSTARD
NUCLEIC ACIDS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
SULFONIC ACID ESTERS
550700 -- Microbiology
59 BASIC BIOLOGICAL SCIENCES
ALKYLATING AGENTS
AMINES
ANIMALS
ARTHROPODS
BIOLOGICAL EFFECTS
CELL DIVISION
CELL KILLING
CHROMOSOMES
DIPTERA
DNA
DROSOPHILA
ESTERS
FLIES
FRUIT FLIES
GENETIC EFFECTS
GENETIC MAPPING
INSECTS
INVERTEBRATES
LARVAE
MAPPING
MEIOSIS
METHYL METHANESULFONATE
MUTAGENS
MUTANTS
NITROGEN MUSTARD
NUCLEIC ACIDS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
SULFONIC ACID ESTERS